1. IVardenafil Hydrochloride Ividiyo yempushana-AASraw

 

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2. Raw I-Vardenafil HCL Izinhlamvu Eziyisisekelo Zempushana

Igama:	UVardenafil hydrochloride (Levitra) powder
CAS:	224785-91-5
Ifomula Yamamolekhula:	C22H19N3O4
Isisindo Yamamolekhula:	389.4
I-Melt Point:	I-298-300 ° C
Isitoreji Sokugcina:	I-20ºC
Umbala:	White Powder

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3. Raw I-Vardenafil HCL Umbiko Wokuhlola Impuphu-HNMR

Iyini i-HNMR futhi I-HNMR spectrum ikutshelani? H I-spectroscopy ye-Nuclear Magnetic Resonance (NMR) iyindlela yamakhemikhali yokuhlaziya esetshenziswa ekulawuleni ikhwalithi nokucwaninga ukuze kutholwe okuqukethwe nokuhlanzeka kwesampula kanye nesakhiwo salo samangqamuzana. Isibonelo, i-NMR ingahlaziya ngokwesilinganiso izingxube eziqukethe izinhlanganisela ezaziwayo. Ezihlanganisweni ezingaziwa, i-NMR ingasetshenziswa ukuze ifane nelabhulali ye-spectral noma ukucabangela isakhiwo esiyisisekelo ngokuqondile. Uma isakhiwo esiyisisekelo sesaziwa, i-NMR ingasetshenziswa ukunquma ukuhambisana kwamangqamuzana esixazululweni kanye nokufunda izici ezibonakalayo ezingeni lamangqamuzana njengokushintshisana kokuvumelana, izinguquko zesigaba, ukunyibilika, kanye nokusabalalisa.

4.Iyini i-Vardenafil Hydrochloride(Vardenafil HCL) Powder?

I-Vardenafil Hydrochloride ingeyesigaba sezidakamizwa ezaziwa ngokuthi i-phosphodiesterase type 5 inhibitors, eyaziwa nangokuthi i-PDE-5 inhibitors. Kulesi sihloko, sizobhekisela kuVardenafil HCL njengegama elifushane.

I-Vardenafil yaziwa nangokuthi i-Levitra noma i-Staxyn. Kungakhathaliseki igama lomkhiqizo, lo muthi ufeza injongo efanayo: ukusiza amadoda ukuba anqobe ukungasebenzi kahle kwe-erectile kanye unomphela.

I-AASraw inikeza i-vardenafil yangempela ye-HCL i-powder yobuningi yokungasebenzi kahle kwe-erectile futhi iye yaziwa iningi labahlinzeki abathengisa amaphilisi noma amaphilisi e-vardenafil hcl, banikeze ukubuyekezwa okuhle ku-Vardenafil HCL powder ehlanzekile.

I-5.Isebenza kanjani i-Vardenafil HCL?

I-Vardenafil HCL kanye namanye ama-PDE5 inhibitors asebenza ngokwandisa ukugeleza kwegazi epipini ukuze aphathe i-ED. Ukuqonda ukuthi le mithi isebenza kanjani kusizwa ukuqonda inqubo yokumiswa.

Uma uqhanyelwe ucansi, ubuchopho bakho buthumela isignali emithanjeni yegazi esepipini lakho, okubangela ukuba ikhiphe ikhemikhali ebizwa ngokuthi i-nitric oxide. I-nitric oxide isakazeka kuyo yonke imithambo yakho yegazi, ikhuthaze ukwakheka kwelinye i-molecule eyaziwa ngokuthi i-cGMP. I-cGMP iphumuza imithambo yegazi epipini lakho, ivumele igazi eliningi ukuthi ligelezele ezicutshini zayo.

I-Vardenafil HCL ivimbela i-PDE5 enzyme, enesibopho sokuwohloka kwe-cGMP. Ukuvimbela le enzyme kuphakamisa izinga le-cGMP emithanjeni yakho yegazi, okuvumela igazi eliningi ukuba ligelezele epipini lakho.

I-6.Ingabe i-Vardenafil HCL iyasebenza kuzo zonke izinhlobo ze-erectile dysfunction?

I-ED yisimo esiyinkimbinkimbi esinezimbangela ezihlukahlukene ezingase zibe khona, okuhlanganisa ukungalingani kwama-hormone okubangelwa ukungahambi kahle kwegazi, ukucindezeleka, ukukhathazeka, ukucindezeleka, nokungasebenzi kahle kwezinzwa.

I-Vardenafil nezinye i-PDE5 inhibitors zivame ukusetshenziswa njengokwelashwa komugqa wokuqala lapho kusolwa izimbangela ezingokomzimba ze-ED. Kungaba usizo, isibonelo, uma ukungahambi kahle kwegazi kuhlotshaniswa nesifo sikashukela noma isifo senhliziyo. I-ED yakho idalwe umthombo othembekile. I-PDE5 inhibitors ayisebenzi ekwelapheni i-ED ebangelwa izici ezingokwengqondo ezinjengokucindezeleka noma ukukhathazeka. Uma kusolwa izimbangela ezingokwengqondo, udokotela angase atuse ukwelashwa kwengqondo.

I-7.I-Vardenafil HCL ihlala isikhathi esingakanani?

I-Vardenafil HCL, ukwelashwa kwe-ED, ingathatha noma yikuphi ukusuka ku-25 kuya kumaminithi we-60 ukusebenza. Khumbula, nokho, ukuthi uzokwazi kuphela ukuthola i-erection uma kune-stimulus yocansi. Ngeke ube nokuqhanyelwa ngisho nangemva kwemizuzu engama-60 uma singekho isikhuthazo socansi. Umuthi uzobe usebenza emzimbeni wakho amahora ayisishiyagalombili kuya kwayishumi.

I-8.I-Vardenafil HCL Powder iqhathaniswa kanjani ne-powder efanayo ye-sex enchaner?

I-Vardenafil HCL powder iyi-PDE5 inhibitor, efana ne-sildenafil citrate (Viagra). Umuthi wesibili ovame ukunqunywa wokungasebenzi kahle kwe-erectile (endaweni yesibili ku-Viagra). I-Vardenafil HCL powder isebenza ngokufanayo ne-sildenafil citrate ngoba ikhulula imithwalo yegazi e-penis, okuvumela ukwanda kwegazi nokumiswa.

Kukhona umehluko omncane phakathi kwale mithi emibili, noma kunjalo, eyenza i-Vardenafil HCL powder ithandeke kakhulu:

♦ I-Vardenafil HCL powder ingathathwa njengoba kudingeka; akudingekile ukuyithatha nsuku zonke noma masonto onke.

♦ Udokotela wakho angase anikeze i-Vardenafil HCL ngesilinganiso esiphansi kunalokho ayezokwenza i-sildenafil citrate.

I-9.Iyini imiphumela emibi ye-Vardenafil HCL?

Ukuze unciphise ubungozi bemiphumela engemihle, sicela wazise umhlinzeki wakho wezokwelapha ngayo yonke imithi oyiphuzayo, okuhlanganisa nemithi kadokotela kanye neyokuthenga ezitolo, amavithamini, nezithako zemithi.

Njengoba kuneminyaka engaphezu kwe-20 emakethe, kunolwazi oluningi mayelana nemiphumela emihle ye-Vardenafil HCL ku-erectile dysfunction kanye nemiphumela yayo emibi engase ibe khona.

Okulandelayo yimiphumela emibi kakhulu ye-Vardenafil HCL:

▪ Ikhanda elibuhlungu

 Ukukhipha isikhumba

▪ isisu esibuhlungu

▪ Ukubona okungavamile noma okufiphele

 Ikhala eligelezayo noma eliminyene

▪ Ubuhlungu bomhlane noma imisipha

▪ Isiyezi nesicanucanu

▪ Ukuqubuka

Eminye imiphumela emibi ingenzeka. Uma noma yikuphi kwalokhu noma eminye imiphumela emibi ikukhathaza noma ingasuki, yeka ukuphuza imithi, thintana nomhlinzeki wakho wokunakekelwa kwezempilo, noma ufune usizo lwezempilo oluphuthumayo.

10.Sommary

I-Vardenafil Hydrochloride ingeye-PDE-5 inhibitors futhi sivame ukuyisebenzisela ukwelapha inkinga ye-ED eyabangelwa izinkinga ezingokomzimba ezifana nokungahambi kahle kwegazi.

I-AASraw ingumkhiqizi ochwepheshe we-Vardenafil HCL powder onelebhu ezimele kanye nefektri enkulu njengokusekela, konke ukukhiqizwa kuzokwenziwa ngaphansi komthetho we-CGMP kanye nesistimu yokulawula ikhwalithi elandelekayo. Uhlelo lokuhlinzeka luzinzile, ama-oda okuthengisa nama-wholesale amukelekile.

11.Ireferensi

[1] Bódi B, et al. Ukuvinjelwa Kwesikhathi Eside Se-PDE-5A Kuthuthukisa Umsebenzi We-Myofilament Ku-Cardiomyocyte Ye-Ventricular Yesokunxele Nesokudla Ngezinqubo Ezihluke Ngokwengxenye Ezinhliziyo Zegundane Lesifo Sikashukela. Ama-Antioxidants (i-Basel). 2021 Nov 6. 10(11):1776.

[2] Wayman C, Phillips S, Lunny C, Webb T, Fawcett L, Baxendale R et al. I-Phosphodiesterase 11 (PDE11) ukulawulwa kwe-spermatozoa physiology. I-Int J Impot Res 2005; 17: 216-223 .

[3] Shabsigh R, Burnett AL, Eardley I, Sharlip ID, Ellsworth PI, Garcia CS et al. Isikhathi kusukela ekudoseni kuya ekuzameni kocansi emadodeni athatha i-tadalafil ezivivinyweni zomtholampilo. BJU Int 2005; 96: 857–863.

[4] U-Oudot A, et al. Inhlanganisela ye-BAY 60-4552 kanye ne-vardenafil isebenzisa imiphumela ye-proerectile facilitator kumagundane anokulimala kwe-cavernous nerve: ubufakazi bocwaningo lomqondo wokwelashwa kwe-phosphodiesterase uhlobo lwe-5 inhibitor ukwehluleka. I-Eur Urol. 2011 Nov. 60(5):1020-6.

[5] Gresser U, et al. Ukungasebenzi kahle kwe-Erectile: ukuqhathanisa ukusebenza kahle kanye nemiphumela emibi ye-PDE-5 inhibitors sildenafil, vardenafil kanye ne-tadalafil-ukubuyekezwa kwezincwadi. I-Eur J Med Res. 2002 Okthoba 29. 7(10):435-46

12. Indlela yokuthenga i-Vardenafil HCL Powder kusuka ku-AASraw?

❶Ukuze usithinte ngohlelo lwethu lokubuza nge-imeyili, noma usishiyele inombolo yakho ye-whatsapp, omele ikhasimende lethu (CSR) uzoxhumana nawe emahoreni ayi-12.

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❹Inkokhelo yenziwe futhi izimpahla zizothunyelwa emahoreni angu-12.

❺Izimpahla ezitholiwe bese unikeza imibono.

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