I-TAK-438 powder (1260141-27-2) powder - Umhlinzeki Wefektri Yomkhiqizi
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I-TAK-438

Isilinganiselwa: Isigaba:

I-TAK438, eyaziwa nangokuthi i-Vonoprazan Fumarate, umuthi omusha wokwelapha izifo ezihlobene ne-asidi ngendlela yokusebenza yenoveli ebizwa nge-potassium-competitive acid blockers (P-CABs) evimbela ngokuncintisana ukubophelwa kwama-ion e-potassium ku-H +, K + -ATPase ( okwaziwa nangokuthi iphampu ye-proton) esiteji sokugcina sokukhipha i-gastric acid kumaseli esiswini separietali, ilawula uketshezi lwe-gastric acid. Inikeza umphumela wokuvimbela we-asidi oqinile futhi oqinile.

Product Incazelo

Izici Eziyisisekelo

Igama Product I-TAK-438 powder
CAS Inombolo 1260141-27-2
Formula Yamamolekhula C21H20FN3O6S
Isisindo sesisindo 461.46
omqondofana I-Vonoprazan Fumarate;
I-TAK-438 powder;
1260141-27-2;
I-Vonoprazan fumurate;
TAK438.
ukubukeka I-white to off-white powder
Isitoreji nokuphatha Okomile, okumnyama naku-0 - 4 C isikhathi esifushane (izinsuku kuya emavikini) noma -20 C isikhathi eside (izinyanga kuya eminyakeni).

 

Incazelo ye-TAK-438 powder

I-TAK438, eyaziwa nangokuthi i-Vonoprazan Fumarate, umuthi omusha wokwelapha izifo ezihlobene ne-asidi ngendlela yokusebenza yenoveli ebizwa nge-potassium-competitive acid blockers (P-CABs) evimbela ngokuncintisana ukubophelwa kwama-ion e-potassium ku-H +, K + -ATPase ( okwaziwa nangokuthi iphampu ye-proton) esiteji sokugcina sokukhipha i-gastric acid kumaseli esiswini separietali, ilawula uketshezi lwe-gastric acid. Inikeza umphumela wokuvimbela we-asidi oqinile futhi oqinile.

Ezingxenyeni zesisu esisetshenzisiwe, ukwelashwa kwe-TAK-438 powder kuholele ekuvimbeleni ukwakheka kwe-asidi okude futhi okuqinile. Umphumela wokuvimbela we-TAK-438 powder ekusithekeni kwe-asidi ubukeke uhambisana ne-gastric parietal cell physiology.

 

I-TAK-438 powder Indlela Yokusebenza

I-TAK-438 powder (i-Vonoprazan fumarate) iyisakhi se-pyrole esivela ne-potassium-yokuncintisana i-acid blocker (P-CAB) evimba ngokuncintisana indawo ebopha i-potassium yesisu esiswini H (+), K (+) - ATPase, i-enzyme esemqoka ku inqubo ye-gastric acid secretion. Ikhompiyutha inganqwabelana ezindaweni ezine-asidi futhi kufanele inikeze isikhathi eside sokuvimbela ngenxa ye-alkaline pKa ka-9.06.

Ezingxenyeni zesisu esisetshenzisiwe, ukwelashwa kwe-TAK-438 powder kuholele ekuvimbeleni ukwakheka kwe-asidi okude futhi okuqinile. Umphumela wokuvimbela we-TAK-438 powder ekusithekeni kwe-asidi ubukeke uhambisana ne-gastric parietal cell physiology.

 

Isicelo se-TAK-438 powder

I-TAK-438 powder (i-Vonoprazan fumarate noma i-Vonoprazan) umuthi omusha wokwelapha izifo ezihlobene ne-acid ngendlela yokusebenza yenoveli ebizwa nge-potassium-competitive acid blockers (P-CABs) evimbela ngokuncintisana ukuboshwa kwama-potassium ion ku-H +, K + - I-ATPase (eyaziwa nangokuthi yipompo yeproton) esinyathelweni sokugcina sokukhishwa kwe-gastric acid kumaseli esiswini separietali. Lesi sidakamizwa sivunyelwe eJapan ekwelashweni kwezifo ezihlobene ne-asidi, kufaka phakathi isilonda esiswini, isilonda se-duodenal, i-reflux esophagitis ne-Adjunct to Helicobacter pylori eradication esimweni seHelicobacter pylori gastritis.

 

Imiphumela emibi ye-TAK-438 Side & Warning

Imiphumela emibi ejwayelekile ifakiwe:

▪ Uhudo,

▪ isicanucanu nokuhlanza,

▪ ukuqunjelwa,

▪ ubuhlungu besisu,

▪ ukuqubuka kwesikhumba,

▪ isilungulela.

 

Lokhu akuyona yonke imiphumela emibi engaba khona ye-TAK438. Ngeminye imininingwane, buza udokotela wakho noma usokhemisi. Shayela udokotela wakho ukuthola iseluleko sezokwelapha mayelana nemiphumela engemihle. Ungabika imiphumela emibi ku-FDA ku-1-800-FDA-1088.

 

Izikhombo

[1] Arikawa Y, Nishida H, Kurasawa O, Hasuoka A, Hirase K, Inatomi N, Hori Y, Matsukawa J, Imanishi A, Kondo M, Tarui N, Hamada T, Takagi T, Takeuchi T, Kajino M. Ukutholwa okususelwa ku-pyrrole novel 1- [5- (2-fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e fumarate (TAK-438 powder) njengomncintiswano we-potassium i-acid blocker (P-CAB). UJ Med Chem. 2012 Meyi 10; 55 (9): 4446-56. i-doi: 10.1021 / jm300318t. I-Epub 2012 Apr 30. I-PubMed PMID: 22512618.

[2] UKondo M, uKawamoto M, uHasuoka A, uKajino M, u-Inatomi N, uTarui N. Ukuhlolwa okuphezulu kwe-potassium-yokuncintisana kwe-acid blockers. Isikrini se-J Biomol. 2012 Feb; 17 (2): 177-82. i-doi: 10.1177 / 1087057111421004. I-Epub 2011 Sep 22. I-PubMed PMID: 21940711.

[3] UShin JM, Inatomi N, Munson K, Strugatsky D, Tokhtaeva E, Vagin O, Sachs G. Ukuchazwa kwe-block potassium-yokuncintisana i-acid blocker ye-gastric H, K-ATPase, 1- [5- (2-) i-fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e monofumarate (TAK-438 powder). UJ Pharmacol Exp Ther. 2011 Nov; 339 (2): 412-20. i-doi: 10.1124 / jpet.111.185314. I-Epub 2011 Aug 9. I-PubMed PMID: 21828261; I-PubMed Central PMCID: PMC3199995.

[4] UHori Y, Matsukawa J, Takeuchi T, Nishida H, Kajino M, Inatomi N. Ucwaningo oluqhathanisa umphumela we-antisecretory we-TAK-438 powder, i-block potassium-yokuncintisana i-acid blocker, ene-lansoprazole ezilwaneni. UJ Pharmacol Exp Ther. 2011 uJun; 337 (3): 797-804. i-doi: 10.1124 / jpet.111.179556. I-Epub 2011 Mar 16. I-PubMed PMID: 21411494.

[5] Matsukawa J, Hori Y, Nishida H, Kajino M, Inatomi N. Ucwaningo lokuqhathanisa ngezindlela zesenzo se-TAK-438 powder, i-novel potassium-yokuncintisana i-acid blocker, kanye ne-lansoprazole kuzinhlayiya eziyisisekelo zikalayini zesisu. I-Biochem Pharmacol. 2011 Meyi 1; 81 (9): 1145-51. i-doi: 10.1016 / j.bcp.2011.02.009. I-Epub 2011 Mar 1. I-PubMed PMID: 21371447.

[6] UHori Y, Imanishi A, Matsukawa J, Tsukimi Y, Nishida H, Arikawa Y, Hirase K, Kajino M, Inatomi N. 1- [5- (2-Fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e monofumarate (TAK-438 powder), i-novel blocker enamandla kakhulu yokuncintisana kwe-acid yokwelapha izifo ezihlobene ne-acid. UJ Pharmacol Exp Ther. 2010 Okthoba; 335 (1): 231-8. i-doi: 10.1124 / jpet.110.170274. I-Epub 2010 Jul 12. I-PubMed PMID: 20624992.