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I-MMAD (i-Demethyldolastatin 10)

Isilinganiselwa:
5.00 koku 5 ngokusekelwe ku 1 isilinganiso ikhasimende
SKU: 203849-91-6. Isigaba:

I-AASraw ikwazi ukuhlanganisa nokukhiqiza ikhono kusuka kugramu kuya ku-mass order ye-MMAD (i-Demethyldolastatin 10) (i-CAS 203849-91-6), ngaphansi komthethonqubo we-CGMP kanye nesistimu yokulawula ikhwalithi.

Ngaphezu kwalokho, MMAD kubikwa ukuthi lisetshenziselwa ukukhiqizwa kwe-anti-drug conjugates (NDCs). Ku-NDCs, i-MMAD ihlangene ne-anti-5T4 antibody noma anti-Her2 antibody. Kuboniswa ukuthi ama-NDC abonisa ukuphumelela okungcono nakwe-pharmacokinetics.

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I-MMAD (Demethyldolastatin 10) ividiyo


I-MMAD (Demethyldolastatin 10) Abalingiswa basisekelo

Igama: I-MMAD (i-Demethyldolastatin 10)
CAS: 203849-91-6
Formula Yamamolekhula: C41H66N6O6S
Isisindo somzimba: 771.06
I-Melt Point: N / A
Isitoreji Sokugcina: I-Powder -20 ° C iminyaka engu-3
I-4 ° C iminyaka engu-2
Kuxazululwe -80 ° C izinyanga ezingu-6
-20 ° C inyanga ye-1
Umbala: Mhlophe ukuya emhlophe (okuqinile)


I-MMAD (Demethyldolastatin 10) (ukusetshenziswa kwe-203849-91-6) kumjikelezo we-steroids

Amagama

Ama-synonyms: i-Demethyldolastatin 10 (203849-91-6); i-Monomethylauristatin D; i-Monomethyl Dolastatin 10
Chemical Name: (S)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide

Isexwayiso ku-MMAD (i-Demethyldolastatin 10)

Umkhiqizo awuqinisekisiwe ngokugcwele kwezicelo zezokwelapha. Ukusebenzisa ucwaningo kuphela

Ukuze uthole ukutholakala kwamandla okushisa, sicela uthulule ithubhu ku-37 ℃ bese uyisigeza endaweni yokugeza yama-ultrasonic okwesikhashana. Isixazululo seStock singagcinwa ngezansi -20 ℃ izinyanga ezimbalwa.

Imiyalo eyengeziwe

I-Vitro: I-MMAD (i-Demethyldolastatin 10) (i-203849-91-6) ihlangene ngenqubo enqabile ye-oxime-ligation yokukhiqiza ama-conjugate amancane (anticogenous anti-antibody-adju) ama-ADCs ambalwa ahambisana ne-drug-to-antibody ratio of ~ 2.0. Ama-conjugates aphumela ekuboniseni izinto ezinhle ze-pharmacokinetic, umsebenzi onamandla we-vitro cytotoxic ngokumelene namaseli omdlavuza we-HER2 +. Uma kuqhathaniswa ne-ADCs elungiselelwe i-cysteine ​​alkylation ngemuva kokunciphisa kwe-disulfide yokudalwa kwamanye amazwe, izindawo eziqondene nendawo ezingekho emvelo-i-amino-acid-based ADCs ziboniswa ukuthi zanda nge-vitro cytotoxicity

E-Vivi: I-conjugate ye-anti-drug-conjugates (i-ADCs) ephumela ekuboniseni i-tumor regression yokugulisa ama-rodents. Baphinde babe nesiphrofayli esithuthukisiwe se-toxicology kuma-rats.


Indlela yokuthenga i-MMAD; Thenga i-Demethyldolastatin 10 kusuka ku-AASraw

1.Ukuxhumana nathi nge-imeyili yethu uhlelo lokuphenya, noma isibhakabhaka se-inthanethiummeleli wenkonzo yamakhasimende (CSR).
I-2.Ukusihlinzekela ngobuningi bakho kanye nekheli lakho elibuziwe.
I-3.I-CSR yethu izokunikeza ikhothethini, isikhathi sokukhokha, inombolo yokulandelela, izindlela zokulethwa kanye nosuku lokufika olulinganisiwe (i-ETA).
I-4.Inkokhelo eyenziwe futhi izimpahla zizothunyelwa kumahora we-12 (Ukuhleleka ngaphakathi kwe-10kg).
Ama-5.Goods athola futhi anikeze imibono.


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COA

I-HNMR

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