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Lorcaserin (Belviq) powder

Isilinganiselwa:
3.50 koku 5 ngokusekelwe ku 2 izilinganiso ikhasimende
SKU: 616202-92-7. Isigaba:

I-AASraw inokukwazi ukuqala nokukwazi ukukhiqiza kusuka kugramu ukuya ku-Lorcaserin (Belviq) powder (616202-92-7), ngaphansi komthethonqubo we-CGMP kanye nesistimu yokulawula ikhwalithi.

Kungenalutho

Product Incazelo

Lorcaserin Isingeniso

Ukhiqiza i-drug ephumelelayo nokuphephile kwesisindo kuyisimo esibucayi. Imizamo esikhathini esidlule ifike nemiphumela emibi eminingi enjengomonakalo wenhliziyo. Ngenhlanhla, isifundo esisha sithi i-lorcaserin isisindo sokuphuza isisindo singakusiza ukuba uchithe isisindo esiningi ngaphandle kokudela impilo yenhliziyo yakho. I-Lorcaserin iyilitha elidambisayo lokucindezela ukudla, elivunyiwe yi-FDA ku-2012. Kodwa yini i-lorcaserin? Ngezansi incazelo ejulile yomuthi, isakhiwo sayo samakhemikhali nezakhiwo, ukusetshenziswa, isilinganiso, izinyathelo zokuphepha, nokunye okuningi.

Igama lomkhiqizo: Lorcaserin / BELVIQ (lorcaserin hydrochloride)

IUPAC Name: (5R)-7-chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

I-Lorcaserin (Belviq) ividiyo ye-powder


ILorcaserin (Belviq) powder Izinhlamvu eziyisisekelo:

Igama: Lorcaserin (Belviq) powder
CAS: 616202-92-7
Formula Yamamolekhula: C11H14ClN
Isisindo somzimba: 195.692
I-Melt Point: 212 ° C
Isitoreji Sokugcina: RT
Umbala: I-white to off-white powder


Lorcaserin Isingeniso

Ukhiqiza i-drug ephumelelayo nokuphephile kwesisindo kuyisimo esibucayi. Imizamo esikhathini esidlule ifike nemiphumela emibi eminingi enjengomonakalo wenhliziyo. Ngenhlanhla, isifundo esisha sithi i-lorcaserin isisindo sokuphuza isisindo singakusiza ukuba uchithe isisindo esiningi ngaphandle kokudela impilo yenhliziyo yakho. I-Lorcaserin iyilitha elidambisayo lokucindezela ukudla, elivunyiwe yi-FDA ku-2012. Kodwa yini i-lorcaserin? Ngezansi incazelo ejulile yomuthi, isakhiwo sayo samakhemikhali nezakhiwo, ukusetshenziswa, isilinganiso, izinyathelo zokuphepha, nokunye okuningi.

Igama lomkhiqizo: Lorcaserin / BELVIQ (lorcaserin hydrochloride)

IUPAC Name: (5R)-7-chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Ngezansi isakhiwo samakhemikhali se-lorcaserin ekukhonjisweni kwe-3-D.

Lorcaserin (Belviq) powder

Izakhiwo zeChimicals zeLorcaserin (belviq) (i-CAS 616202-92-7)

Ngezansi izici zamakhemikhali ezifingqiwe zeLorcaserin (belviq); ziye zanikezwa etafuleni elingezansi ukuze zibuke ngokushesha.

Igama lomhlaba I-Property Value
Ukubala kwe-Unit Integrated-Bonded 1
Isotope Atom Count 0
Ukubala okungenakulinganiswa kwesibalo 0
Ukubalwa kwe-Bond Stereocenter Count 0
Ukubala okungenakulinganiswa kwe-Atom 0
Count Count Stereocenter Count 1
Count Atom Count 13
Ukukhokha Okuhlelekile 0
I-Compound I-Canonicalized Yiqiniso
I-XLogP3-AA 2.7
IMisa yangempela I-195.081 g / mol
IMisa ye-Monoisotopic I-195.081 g / mol
Indawo ephezulu yePolological Polar I-12 A ^ 2
kushuba 172
I-Count Bond Count 0
I-Hydrogen Bond Acceptor Count 1
I-Hydrogen Bond Donor Count 1
isisindo Yamamolekhula I-195.69 g / mol
Ama-Constant Constantation

i-pKa = i-9.98 (est)

Incazelo elula ye-Lorcaserin HCL powder

I-Lorcaserin (i-Belviq) iphilisi elicindezelayo elinesifiso esakhiwe yi-Arena Pharmaceuticals. Kungenxa yekilasi lezidakamizwa ezibhekwa njenge-serotonin receptor agonists. Yenzelwe ukusiza uzizwe ugcwele ngemuva kokuthi udle ukudla okuncane. Iqeda ukudla ngokuvuselela i-5-HT2C ama-receptors, okuyizinhlobo ze-receptors ze-serotonin esifundeni sobuchopho (hypothalamus) esilawula ukudla. Uma bekhombisa ukuthi umzimba wakho uzizwa ugcwele, uthola ukudla okuncane, ngaleyo ndlela ugcine ulahlekelwa isisindo ngokuhamba kwesikhathi.

I-Belviq, ogama lakhe elibizwa ngamakhemikhali (R) -8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3- benzazepine hydrochloride hemihydrate, lenzelwe ukuthathwa ngomlomo. Isisindo sayo samangqamuzana i-241.16 g / mol, futhi isakhiwo sayo esiphezulu nguC11H15Cl2N • 0.5H2O. Inkomfa yayo yokwakha ingezansi:

Lorcaserin (Belviq) powder

I-solcasility ye-Lorcaserin hydrochloride hemihydrate emanzini iphakeme kune-400 mg / mL. Ithebhulethi Belviq has 10.4 amamiligremu angaba crystalline lorcaserin hydrochloride hemihydrate (a white off-white powder), okuyinto ilingana 10.0 angu anhydrous lorcaserin hydrochloride. Ibuye ibe nezinye izithako, kuhlanganise magnesium stearate NF, talc USP, FD & C Blue #2 aluminium echibini, ama-titanium dioxide USP, polyethylene glycol NF, polyvinyl utshwala USP, colloidal Silicon dioxide NF, sodium croscarmellose NF, silicified microcrystalline cellulose futhi hydroxypropyl cellulose NF.

Isenzo se-Lorcaserin

Ngokweziqondiso zokuqondisa izidakamizwa ze-Food and Drug Administration (2007), i-Lorcaserin iyakwazi ukusiza abantu abadala ukuba bafeze ukulahlekelwa kwesisindo esibhedlela. Lesi sidakamizwa sokulahlekelwa kwesisindo kuthiwa sisebenza kahle uma sihlangene nomsebenzi wokwenyuka ngokomzimba kanye nokudla okuphansi kwekhalori. Kungasiza kakhulu ngokulawulwa kwesisindo esingapheli, ikakhulukazi kubantu abakhuluphele ngokweqile (okungenani i-27 kg / m2), noma okhuluphele (i-BMI okungenani i-30 kg / m2). Le mithi ingasiza nalabo abanezinkinga ezihlobene nesisindo noma ngaphezulu, ezifana nohlobo lwe-2 sikashukela, i-dyslipidemia, noma umfutho wegazi ophezulu.

I-Lorcaserin iyiphilisi yokunciphisa ukudla enomdla eyenza ngokukhetha njenge-5-HT2C i-receptor agonist ku-hypothalamus enezinyathelo zokukhetha kwezikhathi eziyishumi nesishiyagalolunye ezithandanayo ze-5-HT2C receptors kune-5-HT2A kanye nokwehlisa izikhathi ezingu-100 eziphezulu zokusebenza ze-5-HT2C receptors kune-5-HT2B.

Ama-receptor e-5-HT2C atholakala kuphela ebuchosheni bomuntu futhi atholakala ku-thalamus, hypothalamus, cortex, i-hippocampus, i-plexus ye-choroid, i-cerebellum, ne-amygdala. Ukugqugquzelwa kwama-receptor we-5-HT2C ku-hypothalamus kusebenze ukukhiqizwa kwe-POMC (proopiomelanocortin) ngakho-ke kukhuthaza ukunciphisa isisindo nge-satiety. Le mpikiswano ixhaswa ukuhlolwa okusemthethweni kokuhlolwa kanye nezinye izifundo zocwaningo. Ngenkathi ngokuvamile kucatshangwa ukuthi ama-receptors e-5-HT2C asiza ekulawuleni ukudla, ukuvinjwa kwe-endocrine, nokuzizwa, isimo esiqondile sokusebenza kwesimiso somthetho asiyazi.

Umamukeli EC50 [nM] Ki[nM]
I-5-HT2C 39 13
I-5-HT2B 2380 147
I-5-HT2A 553 92

Ukusetshenziswa kwe-Lorcaserin HCL powder

Uma sibheka ukubuyekezwa kwangempela kwe-Lorcaserin ngaphandle, khona-ke lokhu cishe kuyisisindo esihle kakhulu sepilisi yokulahlekelwa emakethe namuhla. Abantu abathile ngokweqile ngokweqile, okungukuthi, labo abanezimo zezokwelapha ezihlobene nesisindo noma labo abakhuluphele bangakwazi kakhulu ukuzuza kulo mkhiqizo.

Uma isetshenziselwa ngokuhlanganyela nohlelo lokuvotela olugunyazwa udokotela, uhlelo lokudla lokudla ngekhalori elincane, nokuguqulwa kokuphila, i-Lorcaserin ingasiza umuntu enze okuningi kunokuba nje alahlekelwe isisindo - kungasiza ukwehlisa izingozi eziningi zempilo ezihambisana nokukhuluphala, okufaka phakathi umfutho wegazi ophezulu, isifo sikashukela, isifo senhliziyo, nokufa ekuqaleni.

NgokweSikhungo Sokulawulwa Kwezifo, ukulahlekelwa yi-5 kuphela kumaphesenti angu-10 wesisindo somzimba wonke kungabonisa izinzuzo zezempilo ezifana nokuthuthukiswa kwe-ushukela wegazi, i-cholesterol yegazi, nokucindezelwa kwegazi.

Umthamo we-Lorcaserin HCL powder

Abantu abadala kufanele bathathe amaphilisi amabili ngosuku. Ngakho-ke uzodinga ukuthatha amaphilisi e-60 ngenyanga. Ngokusho kwe-FDA, umuntu kufanele asebenzise lesi sidakamizwa phakathi nakho konke ukuphila kwakhe ukuze agcine isisindo esinempilo.

Kubalulekile ukuqaphela ukuthi imiphumela emihle kufanele ibonwe ngemuva kwamaviki angu-12. Uma ungenakulahlekelwa okungenani amaphesenti angu-5 wesisindo somzimba wakho osisisekelo ngaleso sikhathi, uyalwa ukuba uyeke ukusebenzisa iphilisi. Ngisho nokusetshenziselwa okuqhubekayo, akuncane ukuthi uzothola futhi ugcine ukulahlekelwa kwesisindo somzimba.

I-Lorcaserin HCL Yokuqapha

Kuhle ukukhumbula ukuthi uchwepheshe wakho wokunakekelwa kwezempilo uye wakubeka lesi sidakamizwa ngoba baqaphele ukuthi inzuzo oyitholayo iphakeme kunezingozi zemiphumela emibi. Iningi labantu abathatha lesi sidakamizwa ababonisi imiphumela emibi kakhulu.

Ngaphambi kokuba uthathe i-lorcaserin, vumela umuthi wakho wezokwelapha noma udokotela ukuthi wazi ukuthi unesihlungu yini kumuthi; noma ngabe unayo yini enye imithi yokwelashwa. I-Lorcaserin iqukethe izithako ezingasebenzi ezingabangela ukubhekana nokugula noma ezinye izinkinga. Cela umuthi wakho wemithi ukukunika imininingwane eyengeziwe.

Ngaphambi kokuba uthathe lesi sidakamizwa, kwazisa umuthi wakho wezokwelapha noma udokotela mayelana nomlando wakho wezokwelapha, ikakhulukazi izinkinga zezinso, isifo sikashukela, inkinga yesibindi, izifo zenhliziyo (kuhlanganise nesifo senhliziyo, isifo senhliziyo, ukushaya kwenhliziyo, ukuhluleka kwenhliziyo) okungase kwande ingozi erections ebuhlungu / isikhathi eside emadodeni (kufaka phakathi i-penis ekhubazekile, isifo se-Peyronie, i-myeloma eminingi, i-sickle cell anemia, i-leukemia).

Le pilisi ecindezela ukudla ingakwenza ukuphuza ukucabanga kwakho noma ukuzonda. I-marijuana noma utshwala kungenza lezi zimbi zibi nakakhulu. Ungasebenzisi imishini, ushayela, noma wenze noma yini efuna ukuqapha kuze kube yilapho ukwazi ukukwenza ngokucophelela. Nciphisa iziphuzo ezidakayo bese ukhuluma nodokotela wakho uma usebenzisa insangu.

Uma ngabe uthola inqubo yokuhlinza, kuwukuhlakanipha ukuthi utshele udokotela wamazinyo wakho noma wonke udokotela mayelana nayo yonke imikhiqizo oyithathayo (kubandakanya izidakamizwa ezingekho emthethweni, imikhiqizo yemifino kanye nemithi kadokotela).

Uma uhlala nesifo sikashukela, le pilisi yokulahlekelwa isisindo ingathinta ushukela wegazi lakho. Qinisekisa ukuthi uhlola izinga lakho lokushukela ngegazi ngezikhathi ezivamile njengoba welulelwa futhi wabelane ngemiphumela yakho nodokotela. Vumela udokotela wakho ukuba azi ukuthi unesifo se-sugar low. Uchwepheshe wakho wokunakekelwa kwezempilo angadinga ukulungisa uhlelo lwakho lokuzivocavoca, ukudla noma isifo sikashukela.

Lesi sidakamizwa akufanele sithathwe ngesikhathi sokukhulelwa ngoba singalimaza umntwana ongakazalwa. Buza udokotela wakho mayelana nokusetshenziswa kwezinhlobo ezinokwethenjelwa zokulawulwa kokuzalwa. Uma ukhulelwe noma ukhulelwe, tshela uchwepheshe wakho wokunakekelwa kwezempilo ngokushesha.

Kuze kube manje, aziwa ukuthi le mithi idlula ubisi lwebele. Ukuvimbela ukuthi kungenzeka ukuthi usengcupheni enganeni, ukondla uma usebenzisa le mithi ayinconywa. Qiniseka ukuthi uthintana nodokotela wakho ngaphambi kokuba uncelise.

Funda Leaflet Yolwazi Lomsebenzisi ngokucophelela uma itholakala kudokotela wakho ngaphambi kokuba uqale ukusebenzisa i-lorcaserin nanoma yisiphi isikhathi lapho uthola khona ukuvuselelwa. Uma kwenzeka unombuzo, cela umuthi wakho wezokwelapha noma udokotela.

Thatha leli philisi elicindezelayo ngokudla ngomlomo noma ngaphandle kokudla njengoba kuqondiswa ummithi wakho, ngokuvamile izikhathi ezimbili ngosuku. Sebenzisa le mithi njalo ukuze uthole okuningi. Ukukusiza ukuba ukhumbule, thatha iphilisi ngesikhathi esifanayo nsuku zonke.

I-Lorcaserin yisidakamizwa esenza umkhuba. Musa ukwandisa umthamo noma uthathe le pilisi kaningi kunalokho okushiwo. Isimo onakho singahle sithuthukise noma sisiphi isikhathi esisheshayo, futhi ingozi yemiphumela emibi ingakhuphuka.

Ukusebenzisana kwezidakamizwa ezinamandla kungenziwa uma izidakamizwa ezithile zisetshenziselwa kanye ne-lorcaserin iphilisi. Tshela udokotela wakho ngazo zonke izidakamizwa ozisebenzisayo njengamanje, nanoma yikuphi omunye umuthi oqalayo noma oyeka ukuyisebenzisa.

I-pilcaserin isisindo sokulahlekelwa isisindo asivunyelwe ukusetshenziswa ngabantu abancane kuneminyaka eyi-18 ubudala.

Kufanele ngithathe kanjani i-Lorcaserin HCL powder?

Ungahlaziyi, uphule, noma uqede ithebhulethi ekhulisiwe. Vele uyigwinya.

I-Lorcaserin ukucindezela ukudla okunengqondo nje yingxenye yohlelo oluphelele lwezokwelapha olufanele futhi lubandakanye ukuzivocavoca, ukulawula isisindo, ukudla, futhi njalo uvivinye ushukela wegazi lakho. Landela imithi yakho, ukudla okunomsoco, kanye nemigomo yokuzivocavoca kakhulu.

Gcina imithi ekamelweni lokushisa ngaphandle kokushisa nomswakama.

Gcina irekhodi lemali yezidakamizwa ezisetshenziswa kuzo zonke izikhumba. I-pilcaserin isisindo sokuphuza isisetshenziswa sokuhlukunyezwa, futhi kufanele njalo uqaphele uma othile esebenzisa imithi yakho ngaphandle kwemithi noma ngokungafanele.

Ungalokothi wabelane ngemithi ye-lorcaserin nanoma ubani omunye. Gcina isidakamizwa endaweni lapho kungekho muntu ongayithola khona.

Kwenzekani uma ulahlekelwa umthamo we-Lorcaserin?

Mane nje uthathe umthamo ongabanjwanga ngokushesha ukhumbule. Kumele uweqe umthamo ongekho uma isikhathi se-dose ehleliwe esilandelayo siphelile. Ungathathi i-dose eyengeziwe yokwenza umthamo ongabanjwanga.

Kwenzekani uma udlula u-Lorcaserin?

Bheka usizo oluphuthumayo lwezokwelapha noma xhumana nolayini wosizo lwe-Poison ku-1-800-222-1222.

Yini okufanele ngiyigweme ukuthatha ngenkathi i-lorcaserin?

Ungathathi noma yikuphi okunye okungekho emthethweni noma imikhiqizo yokunciphisa isisindo ngaphandle kokuthola iseluleko sikadokotela wakho. Futhi, ungathathi imithi ebandayo noma ekhwehlela lapho uthatha i-lorcaserin pilill.

Yimiphi eminye imithi engathinta i-lorcaserin?

Imithi elandelayo ingathinta indlela i-lorcaserin esebenza ngayo:

  • I "triptan" engumuthi wekhanda we-migraine-njengo-Maxalt, i-Zomig almotriptan, i-rizatriptan, i-sumatriptan, i-frovatriptan, i-zolmitriptan, i-Imitrex, nabanye.
  • I-Cabergoline;
  • linezolid;
  • noma yiluphi uhlobo lwe-antidepressant
  • lithium;
  • Wort John;
  • Erectile dysfunctiondrugs- Levitra, Viagra avanafil, Cialis, sildenafil, tadalafil, nabanye;
  • i-tramadol;
  • i-tryptophan (eyaziwa nangokuthi yi-L-tryptophan);
  • ukukhwehlela noma imithi ebandayo equkethe dextromethorphan; noma
  • imithi yokwelapha ukugula kwengqondo, isimo sengqondo noma ukukhathazeka kokukhathazeka.

Uhlu olungenhla aluphelele. Eminye imithi ingathinta i-lorcaserin, futhi akuwona wonke ukusebenzisana okungenzeka kubekwe kulolu mhlahlandlela wemithi.

Imibiko ye-BBC Kuphephelo Nokusebenza kwe-Lorcaserin HCL (i-CAS 616202-92-7)

Kuye kwaba nemibiko eminingi ye-BBC eLorcaserin ngokuphathelene nokusebenza kahle kodwa nokuphepha kwemithi. Ngokusho kwe-BBC, ukutadisha kwamuva, okushicilelwe eNew England Journal of Medicine, kubonisa ukuthi abantu abasebenzisa i-lorcaserin yokudla iphilisi ecindezelayo balahlekelwa cishe nge-8.8lb (4kg) ngesikhathi sokurekhoda okungenani iminyaka emithathu nengxenye. Imiphumela yalolu cwaningo yafakazela ukuthi i-lorcaserin akungabazeki ukuthi enye yezinsizakalo ezingcono kakhulu zokulahlekelwa isisindo.

Lo mbiko ubuye uthi umuthi njengoba usebenza ngokunciphisa ukudla, ungafaki abasebenzisi engozini enkulu yezimo zenhliziyo.Isifundo esishicilelwe silandele ukukhishwa kwe-12,000 obese noma iziguli ezidlulele ngokweqile e-USA ezinyangeni ezingu-40.

Ngemuva kweminyaka emithathu nengxenye, abantu abadala abathatha i-lorcaserin babephindwe kathathu ngaphezu kokunganciphisi kwamaphesenti amahlanu kuya kweyishumi emzimbeni wabo kunabo abathola i-placebo, kusho omunye wabacwaningi abaholayo, uDkt. Erin Bohula.

Izivivinyo ezenziwa kwi-valve yenhliziyo azange zibonise ukungafani okuphawulekayo uma kuqhathaniswa ne-valves yenhliziyo kulabo abathatha indawo ye-placebo. Njengoba ukhumbule ukuthi lokhu bekulokhu okukhathazeka ngokuyinhloko uma kuziwa ekuphepheni kwamanye amaphilisi amancane, i-lorcaserin ingahle ibe yiphilisi engcono kakhulu yokulahlekelwa isisindo.

Abadala ukuthatha imithi nabo babesengozini ephansi yohlobo lwe-2 yesifo sikashukela. Iphilisi idinga cishe i-£ 155-225 ($ 220-290) ngenyanga umthamo wase-US. Lorcaserin inikeza enye esihle ukuze koda izinqubo isisindo zokunciphisa like esiswini ukuhlinzwa band phakathi kwabanye.

Omunye umbiko we-BBC uveze ucwaningo ngabacwaningi e-University of Aberdeen eRotttt Institute owaqhuba ucwaningo ngesidlo. Ososayensi bathi ukucwaninga kwabo ngokufisa kwakwenze kwaba nengxenye ethile yobuchopho.

Baqaphela ukuthi ngokuthonya lawo maseli ngemithi bakwazi ukunciphisa ukudla. Njengoba i-lorcaserin isebenza ngale ndlela, imiphumela yalolu cwaningo ayivuli kuphela iminyango yemithi emisha efana ne-lorcaserin kodwa futhi yaqinisa lokho ochwepheshe abakukholelwayo mayelana ne-lorcaserin-ukuphepha nokusebenza kwayo.

UKUHLELWA KANYE Nesitatimende:

Le Material ithengiswa Ukusetshenziswa Kocwaningo Kuphela. Imibandela Yokuthengisa Faka isicelo. Hhayi Ukusetshenziswa Komuntu, noma Ezokwelapha, Izilwane, noma Ukusetshenziswa Kwasekhaya.


COA

I-HNMR

Singabantu abahlinzeki be-Lorcaserin powder, i-Belviq powder yokudayiswa, (616202-92-7) hplc =98% | I-HNMR enhle kakhulu

I-AAS eluhlaza inikeza ubungcweti 98% Lorcaserin powder oluhlaza ukuze kube nama-bodybuilders noma ama-labs angaphansi komhlaba okusetshenziswa kwe-fweight-ukulahlekelwa.

Ungadliwa

Okubhekiselweyo nokuhlungwa komkhiqizo

Lorcaserin powder: Zonke izinto mayelana nokulahlekelwa kwezidakamizwa

Imiphumela ye-Lorcaserin: Ingabe i-Lorcaserin powder isebenza ngempela ekulahlekelweni kwamafutha?

Izinto ze-20 ezibaluleke kakhulu Udinga ukwazi nge-Lorcaserin HCL powder

lwezincwadi

  1. Weissman NJ, iSanchez M, Koch GG, et al. Ukuhlolwa kwe-Echocardiographic ye-valvular ye-cardiac yokuphindaphindiwe ne-lorcaserin kusukela ekuhlaziyweni kwesigaba se-3 izilingo zomtholampilo ze-3. I-Circ I-Circ Cardiovasc Imaging 2013; 6: 560-7
  2. I-Halford JC: Izidakamizwa ngokweqile ekuthuthukisweni komtholampilo. Izidakamizwa ze-Curr Opin Investig. 2006 Apr; 7 (4): 312-8.
  3. Thomsen WJ, Grottick AJ, Menzaghi F, et al. I-Lorcaserin, i-novel ekhethiwe yomuntu i-5-hydroxytryptamine2C agonist: i-vitro and in vivo yokuhlukaniswa kwamakhemikhali. J Pharmacol Exp Ther 2008; 325: 577-87
  4. Smith BM, Smith JM, Tsai JH, et al. Ukutholwa nokuhlelwa kobudlelwano-umsebenzi we-Lorcaserin, i-serotonin ekhethiwe ye-serotonin 5-HT2C receptor agonist yokwelapha ukukhuluphala. J Med Chem 2008; 51: 305-13
  5. Izindaba ze-BBC, "A Iqembu elincane leqembu lesikhumbuzo selikwazi ukubhekana nokukhuluphala ngokweqile ngokusho kwabacwaningi base-Aberdeen. "