I-X XUMUMX powder (147-1146963-51) | i-neuroprotective ne-neurotrophic compound
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J 147 powder

Isilinganiselwa: SKU: 1146963-51-0. Isigaba:

I-AASraw ingumkhiqizi ochwepheshe we-J147 Powder ehlanzekile enelebhu ezimele kanye nefektri enkulu njengokusekela, konke ukukhiqizwa kuzokwenziwa ngaphansi komthetho we-CGMP kanye nesistimu yokulawula ikhwalithi elandelekayo. Uhlelo lokuhlinzeka luzinzile, kokubili ama-oda okuthengisa kanye nama-wholesale amukelekile.Siyakwamukela uku-oda kusuka ku-AASraw!

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Product Incazelo

1. J147 powder ividiyo-AASraw

 


2. J147 powder Izinhlamvu Eziyisisekelo

Igama: J 147 powder
CAS: 1146963-51-0
Ifomula Yamamolekhula: C18H17F3N2O2
Isisindo Yamamolekhula: 350.3349896
I-Melt Point: I-177-178 ° C
Isitoreji Sokugcina: 4 ° C
Umbala: I-white powder noma i-white powder

 


3. J147 powder Umbiko Wokuhlola-HNMR

I-J 147 powder HNMR

Iyini i-HNMR futhi I-HNMR spectrum ikutshelani? H I-spectroscopy ye-Nuclear Magnetic Resonance (NMR) iyindlela yamakhemikhali yokuhlaziya esetshenziswa ekulawuleni ikhwalithi nokucwaninga ukuze kutholwe okuqukethwe nokuhlanzeka kwesampula kanye nesakhiwo salo samangqamuzana. Isibonelo, i-NMR ingahlaziya ngokwesilinganiso izingxube eziqukethe izinhlanganisela ezaziwayo. Ezihlanganisweni ezingaziwa, i-NMR ingasetshenziswa ukuze ifane nelabhulali ye-spectral noma ukucabangela isakhiwo esiyisisekelo ngokuqondile. Uma isakhiwo esiyisisekelo sesaziwa, i-NMR ingasetshenziswa ukunquma ukuhambisana kwamangqamuzana esixazululweni kanye nokufunda izici ezibonakalayo ezingeni lamangqamuzana njengokushintshisana kokuvumelana, izinguquko zesigaba, ukunyibilika, kanye nokusabalalisa.

4. Iyini i-J147 Powder?

I-J147 Powder iyi-synthetic derivative ye-curcumin, eyingxenye ye-curry spice turmeric. I-J147 Powder iwukuphuma kwe-Curcumin ne-Cyclohexyl-Bisphenol A (CBA) okuyi-neurogenic ne-neuroprotective.

I-J147 Powder iboniswe ukuthuthukisa kakhulu ukukhubazeka kwengqondo ezigulini ezikhulile ze-Alzheimer's. Lokhu okutholakele kusekelwe kumamodeli ezilwane ezikhula ngokushesha. I-J147 Powder iyimithi ye-neurotrophic esebenza ngomlomo ehlehlisa ukukhubazeka kwengqondo.

I-Curcumin iyi-polyphenol etholakala ku-turmeric ne-ginger.

I-Curcumin inezinzuzo eziningana ezibonisiwe ekwelapheni izifo ezihlukahlukene, kodwa kukhona ukulinganiselwa okucacile ngenxa yamandla ayo abuthakathaka okudlula i-Blood-Brain Barrier (BB).

I-J147 Powder ingawela i-BBB iye ebuchosheni (eqinile) futhi ibangele ukukhiqizwa kwe-neuronal stem cell.

I-J147 Powder, ngokungafani nemithi yamanje ye-Alzheimer's Disease, ayiyona i-acetylcholinesterase inhibitor noma i-phosphodiesterase inhibitor, kodwa ithuthukisa ukuqonda ngokwelashwa kwesikhashana.

Le nootropic ithola ukuduma njengokwelashwa kwesifo i-Alzheimer's. I-J-147 Powder iphinde yabamba intshisekelo yabasebenzisi abanempilo ngenxa yamandla ayo okuthuthukisa inkumbulo, ikhono elikhulayo lokufunda, kanye nempilo yobuchopho isiyonke. Umsebenzisi ofuna ukuthenga i-J147 Powder, kufanele ayithenge nomkhiqizi wangempela, ukuze uthole intengo ye-powder J-147 yefekthri ukuze wonge imali.

5. Isebenza kanjani i-J-147?

Umthelela we-J-147 kumaseli wawungaziwa kwaze kwaba yilapho i-Salk Institute neurobiologists ixazulula indida ngo-2018. I-J-147 isebenza ngokubophezela ku-ATP synthase. Le phrotheni ye-mitochondrial ilawula inqubo yokuguga ngokushintsha ukukhiqizwa kwamandla eselula. Ukuba khona kwe-J-147 Powder ohlelweni lomuntu kugwema ubuthi obuhlobene neminyaka obubangelwa i-mitochondria engasebenzi kanye nokukhiqizwa ngokweqile kwe-ATP.

Indlela yokusebenza ye-J-147 Powder izophinda ikhulise amazinga ama-neurotransmitters ahlukahlukene njenge-NGF ne-BDNF. Ngaphezu kwalokho, kunciphisa amazinga e-beta-amyloid, ahlala ephakanyisiwe ezigulini ze-Alzheimer kanye ne-dementia. Imiphumela ye-J-147 ihlanganisa ukunciphisa ukuqhubeka kwesifo i-Alzheimer's, ukuncipha kokulahlekelwa yinkumbulo, nokwandisa ukudalwa kwamaseli e-neuronal.

Izifundo eziningana nge-J-147 Powder zenziwe kumagundane. Isivivinyo somuntu senziwa ngo-2020, nokho, imiphumela egcwele ayikabiwa.

6. Izinzuzo of I-J147 powder

Ithuthukisa Umsebenzi We-Mitochondrial Futhi Isikhathi sokuphila

I-J147 Powder iphumelela kakhulu ekwehliseni ingcindezi ye-oxidative futhi ithuthukise ukusebenza kwe-mitochondrial.

Isibonelo, i-J147 Powder yandisa umsebenzi we-mitochondrial ngokuthuthukisa amazinga e-ATP (ukuvimbela i-ATP synthase, ikakhulukazi i-ATP5A).

I-J147 Powder inganciphisa ama-metabolite ayingozi aholela ku-excitotoxicity ngokuvimbela i-ATP synthase.

Ezingeni le-biochemical, lokhu kuthuthukisa i-mitochondria ebusheni/enempilo eyengeziwe (ngokushintsha indlela ye-AMPK/mTOR).

 Ivimbela Isifo i-Alzheimer's

I-J147 Powder yelapha ukukhubazeka kwengqondo kumodeli yamagundane esifo i-Alzheimer (AD).

I-J147 Powder ingakhuthaza i-Amyloid-Beta (A) metabolism futhi inciphise amazinga ebuchosheni ngokwehlisa amazinga amaprotheni -Secretase (BACE).

I-J147 Powder ingavikela i-homeostasis ye-BBB futhi ithuthukise ukusebenza kwemithambo kumamodeli ezilwane zesifo i-Alzheimer's.

I-J147 Powder ingaphinda inyuse kakhulu amazinga e-Docosahexaenoic Acid (DHA) ebuchosheni.

Kungasiza ukubuyisela amazinga e-Glutamate ebuchosheni (akhiqizwa ku-TCA intermediate -ketoglutarate).

Kuthuthukisa Inkumbulo

Ithuthukisa ukuqonda kuwo womabili amagundane esifo i-Alzheimer kanye nezinhlobo zezilwane ezineminyaka evamile.

I-J147 Powder ingabuyisela ukukhubazeka okuphawulekayo kwengqondo ngisho nasezilwaneni ezindala kakhulu.

I-J-147 ingasiza futhi ngenkumbulo yendawo kanye Nokuqina Kwesikhathi Eside (LTP).

Ukukhula Kobuchopho

I-J 147 Powder inamandla okuthuthukisa nokugqugquzela i-synaptic plasticity ebuchosheni.

I-J 147 Powder ikhuthaza i-synaptic plasticity ngokugcina inkulumo ye-Synaptophysin (iphrotheni ye-synaptic vesicle eyancipha kokubili ukuguga kanye ne-AD futhi ibhekwa njenge-biomarker yokulahlekelwa kwe-synapse).

I-J-147 Powder ikhuthaza ukukhula kobuchopho ngokukhuphula amazinga e-Nerve Growth Factor (NGF) kanye ne-Brain-Derived Neurotrophic Factor (BDNF) (BDNF).

Ivikela Ama-Neurons

I-J 147 Powder ayidingi i-BDNF ukuthi ibe yi-neuroprotective.

I-J 147 Powder iphinde ivikele ama-neurons ekuntulekeni kwe-glutathione (GSH).

I-J-147 Powder ivikela ubuchopho ekuncishweni ushukela.

Ebuchosheni be-AD, i-5-Lipoxygenase (5-LOX) iqoqa amangqamuzana omzimba amaningi ukuze abangele impendulo yokuvuvukala, futhi i-Heme Oxygenase 1 (HO-1) yenza njenge-pro-oxidant esikhundleni se-antioxidant.

I-Curcumin derivative J147 Powder inamandla okwehlisa amazinga e-HO-1 kanye nokuvimbela i-5-LOX.

Ingasithuthukisa Isifo Sikashukela

Kumamodeli ezilwane, i-J147 Powder ibonise ukwehlisa amazinga e-Glucose ne-HbA1c ngokwandisa i-AMPK.

Nakuba kungabalulekile, i-J147 Powder ingase futhi ithuthukise umsebenzi wamaseli e-beta asele kusifo sikashukela.

Ilwa Nobuhlungu kanye Neuropathy

I-J-147 Powder yafakazelwa ukuthi iyasebenza ekwelapheni i-Diabetic Neuropathy kumodeli yezilwane ezinesifo sikashukela sohlobo loku-1.

Kungasiza ukunciphisa ukungasebenzi kahle kwe-motor nerve okubangelwa isifo sikashukela, ukuzwela kwe-peripheral, namazinga obuhlungu.

⑧Ingase Ithuthukise Ukukhathazeka

I-J147 Powder inamandla okunciphisa amazinga okukhathazeka.

I-J147 Powder ikwazile ukunciphisa amazinga okukhathazeka ngesikhathi sokuhlolwa kwe-maze kumamodeli ezilwane ane-AD.

7. J147 Impushana dose kanye nesitaki

Izifundo ezahlukahlukene zisebenzise imithamo ehlukene kumagundane, kepha esinye sezifundo ezibuyekezwe kangcono sanikeza amagundane i-10 mg / kg yesisindo somzimba ngosuku. Olunye ucwaningo lusebenzise imithamo ye-1, 3 noma i-9 mg / kg, futhi lathola imiphumela encike kumthamo, imithamo ephakeme isebenza kangcono.

Kodwa-ke, ukuhumushela lokhu kumthamo womuntu kudinga ukulungiswa kwendawo engaphezulu komzimba. Ngokwefomula yokuguqula esetshenziswa kakhulu, isilinganiso esilingana nomuntu kufanele silingane nomthamo wegundane ohlukaniswe ngo-12.3 – noma .81 mg ngekg yesisindo somzimba ngosuku.

Ezinye zezinzuzo zizobonakala ngokushesha nje lapho uqala ukuyisebenzisa. Ngisho nokwelashwa kwesikhashana, i-J-147 iveza imiphumela esheshayo efana ne-antidepressant kumagundane esikhathini esiyizinsuku ezingu-3 ngaphandle kokusungula ukubekezelelana kwezidakamizwa noma ukuqonda okwengeziwe. Kunenqwaba ye-J147 Powder ethengiswa ku-inthanethi, kubalulekile ukuthenga umkhiqizo wangempela nosezingeni eliphezulu. Ungathenga i-J147 Powder Wholesale nomphakeli we-AASRAW.

I-J147 ibikade ingadumile kubantu abanempilo isikhathi eside ngokwanele ukuba sincome ngokuzethemba noma yiziphi izitaki. Akuwona wonke ama-nootropics 'angahlanganiswa futhi afaniswe' ngokuphepha.

8. I-J147 powder huma tama-rials and uukuba eisipiliyoni

Ucwaningo lokuqala lwabantu lwe-J147 Powder lubhalisiwe futhi kulindeleke ukuthi luqedwe ngo-2020. Kubonakala sengathi lwenziwe njengesivivinyo sesigaba 1 kubantu abangu-64 abanempilo, ngomgomo oyinhloko wokuhlola ukuphepha kanye ne-pharmacokinetics (i-half-life, side. imiphumela, ukugxila kwezicubu) ze-J147 Powder, kunokuba usizo lwayo ekwelapheni noma yisiphi isimo.

Yize okutholwe yilolu cwaningo kungakadalulwa kodwa siyazi ukuthi kubonakale kuphothulwe ngaphandle kwezinkinga ezinkulu.

Nakuba i-J147 Powder iyikhemikhali yocwaningo futhi sekuxoxiwe ngayo emiphakathini eminingana ye-nootropics, akukaze kube nemibiko eminingi yabasebenzisi enikeziwe kuze kube manje, futhi abantu abaningi balinde ukubona ucwaningo olwengeziwe ngaphambi kokuyisebenzisa. Ngokusho kwabasebenzisi be-J-147 Powder, Kulula ukuthenga i-J147 powder ku-intanethi, ukuthola umphakeli we-J147 Powder ongokoqobo uzochitha izikhathi ezithile. Umhlinzeki we-AASRAW uhlinzeka ngekhwalithi ephezulu ye-J-147 Powder. Uma wenza izithasiselo ze-J-147, ungathenga inqwaba ye-J147 Powder ukuze ujabulele intengo enhle.

Iningi labantu libonakala lingayiboni imiphumela ebonakala ekuhlangenwe nakho okumbalwa kwabasebenzisi okubikiwe. Nakuba abasebenzisi bevame ukuba basha futhi benempilo futhi isikhathi sokusebenzisa sivame ukuba mfushane kakhulu kunezifundo, i-curcumin derivative J147 Powder ingase ingabi nemiphumela ephawulekayo ye-nootropic kubantu abadala abanempilo.

Singakwazi ukuqagela kuphela ukuthi i-J147 Powder ingaba usizo kangakanani uma lungekho ucwaningo lwabantu noma ama-anecdotes adumile. Ngombono, noma yini ekhulisa amandla e-neuronal metabolism kufanele ibe nemiphumela ye-nootropic, noma kunjalo umsebenzi wakho wokuqonda kungenzeka unganqunyelwe ngempela ukusetshenziswa kwamandla. Kungancika ekutheni imisoco ingangena futhi iphume ngokushesha kangakanani ebuchosheni bakho noma ukuthi imicabango yakho ihlanganiswe kahle kangakanani.

I-Curcumin derivative J147 Powder iphinde ikhiqize izici eziningi ze-neurotrophic, okusho ukuthi ingakwazi ukusiza ubuchopho bakho buthuthukise ama-synapses namaseli obuchopho. Kodwa khumbula ukuthi kungase kube nokweqile kwama-synapses namaseli obuchopho.

Okwamanje asikho isizathu sokukholelwa ukuthi i-J147 Powder izoba nomthelela omkhulu we-nootropic kubantu abadala abasha, abanempilo. Kulabo abanokuwohloka komqondo, cishe kuyazuzisa. Kubantu asebekhulile kancane abazi ukuthi ukuwohloka komqondo kuyenzeka emndenini wabo, kungase kube usizo njenge-nootropic njengoba kungase kumise noma kuhlehlise ukulahlekelwa kwengqondo ngaphambi kokuba kukhule kube ukuwohloka komqondo okusemtholampilo. Kunoma yikuphi, kuzothatha isikhathi ngaphambi kokuba siqiniseke.

9. J-147 Impushana risk kanye si-ide ekuthinta

I-J147 Powder ihlolwe ngokomtholampilo futhi kwatholakala ukuthi iphephile ukusetshenziswa isikhathi eside ngamalebhu azimele. Iphumelele ukuhlolwa kwe-toxicological ezifundweni zezilwane ezidingwa i-Food and Drug Administration (FDA), futhi akukho miphumela engemihle ebhalwe phansi kubantu uma ithathwa ngethamo elinconyiwe (okuxoxwe ngalo kamuva).

10. kuphi ukuthenga i-J-147 Powder?

Ukuba semthethweni kwale nootropic kusaxoxwa ngakho, kodwa ngeke kukuvimbele ekuthengeni izinto ezisemthethweni. Phela, izivivinyo zomtholampilo ze-J-147 Alzheimer's seziqalile. Ungathenga impushana ezitolo eziku-inthanethi njengoba ungaqhathanisa amanani e-J-147 Powder kubathengisi abaningi. Kodwa-ke, kufanele uphequlule ukuze uthole umkhiqizi ohloniphekile onokuhlolwa kwaselabhorethri ezimele.

Uma ufuna enye i-J-147 Powder ethengiswayo, ngena efekthri yethu. Sihlinzeka ngezinhlobonhlobo ze-nootropics ngaphansi kokulawulwa kwekhwalithi okuqinile. Ngokuya ngomgomo wakho we-psychonautic, ungathenga ngobuningi noma ngawodwana. Qaphela ukuthi, intengo ye-J-147 Powder inobungani kuphela uma uthenga ngenani elikhulu.

11.Izilinganiso

[1] I-Pan X, i-Chen L, i-Xu W, i-Bao S, i-Wang J, i-Cui X, i-Gao S, i-Liu K, i-Avasthi S, i-Zhang M, i-Chen R. imiphumela ye-J147.” I-Behav Brain Res. 2021 Aug 6;411:113374. doi: 10.1016/j.bbr.2021.113374. Epub 2021 May 21. PMID: 34023306

[2] Li J, Chen L, Li G, Chen X, Hu S, Zheng L, Luria V, Lv J, Sun Y, Xu Y, Yu Y. “I-Sub-Acute Treatment of Curcumin Derivative J147 Ameliorates Depression-like Behaviour Ngokusayina kwe-cAMP engu-5-HT1A-Mediated.” I-Front Neurosci. 2020 Jul 8; 14:701. doi: 10.3389/fnins.2020.00701. I-eCollection 2020.PMID: 32733195

[3] Jin R, Wang M, Zhong W, Kissinger CR, Villafranca JE, Li G. “J147 Yehlisa I-tPA-Induced Brain Hemorrhage in Acute Experimental Stroke in Rats.”Front Neurol. 2022 Mar 2;13:821082. doi: 10.3389/fneur.2022.821082. eCollection 2022. PMID: 35309561

[4] Emmanuel IA, Olotu FA, Agoni C, Soliman MES. "Ku-Silico Repurposing ye-J147 yokwelashwa kwe-Neonatal Encephalopathy: Ukuhlola Izindlela Ze-Molecular of Mutant Mitochondrial ATP Synthase." I-Curr Pharm Biotechnol. 2020;21(14):1551-1566. doi: 10.2174/1389201021666200628152246. PMID: 32598251

[5] U-Lian L, u-Xu Y, u-Zhang J, u-Yu Y, u-Zhu N, u-Guan X, u-Huang H, u-Chen R, u-Chen J, u-Shi G, u-Pan J. “Imiphumela efana ne-antidepressant yenoveli ephuma ku-curcumin J147: Ukuzibandakanya kwe I-5-HT1A receptor.” I-Neuropharmacology. 2018 Jun;135:506-513. doi: 10.1016/j.neuropharm.2018.04.003. Epub 2018 Apr 5. PMID: 29626566

12. Indlela yokuthenga J147 powder kusuka ku-AASraw?

❶Ukuze usithinte ngohlelo lwethu lokubuza nge-imeyili, noma usishiyele inombolo yakho ye-whatsapp, omele ikhasimende lethu (CSR) uzoxhumana nawe emahoreni ayi-12.

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❹Inkokhelo yenziwe futhi izimpahla zizothunyelwa emahoreni angu-12.

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