I-Alfaxalone (23930-19-0) powder - Umhlinzeki Wefektri Yomkhiqizi
I-AASraw ikhiqiza izimpushana ze-NMN ne-NRC ngobuningi!

I-Alfaxalone

Isilinganiselwa: Isigaba:

I-Alfaxalone iyimolekyuli ye-neuroactive steroid enezinto zokubulala izinzwa okujwayelekile. I-Alfaxalone ichazwa ngamakhemikhali njenge-3-α-hydroxy-5-α-pregnane-11, 20-dione, futhi inesisindo samangqamuzana esingu-332.5…

Product Incazelo

Izici Eziyisisekelo

Igama Product I-Alfaxalone
CAS Inombolo 23930-19-0
Formula Yamamolekhula C21H32O3
Isisindo sesisindo 332.48
omqondofana I-Alphaxalone;

I-Alfaxalone;

23930-19-0;

5alpha-Pregnan-3alpha-ol-11,20-dione;

I-Alfaxalonum.

ukubukeka powder emhlophe
Isitoreji nokuphatha Gcina ekamelweni lokushisa elilawulwayo -20 ° C

 

Incazelo ye-Alfaxalone

I-Alfaxalone iyimolekyuli ye-neuroactive steroid enezinto zokubulala izinzwa okujwayelekile. I-Alfaxalone ichazwa ngamakhemikhali njenge-3-α-hydroxy-5-α-pregnane-11, 20-dione, futhi inesisindo samangqamuzana esingu-332.5. Indlela eyinhloko yesenzo sokubulala izinzwa se-alfaxalone ukuguquguquka kokuthuthwa kwe-neuronal cell membrane chloride ion, okubangelwa ukubopha kwe-alfaxalone ku-GABAA (gamma-aminobutyric acid) cell surface receptors.

 

Indlela yokusebenza ye-Alfaxalone

I-Alfaxalone ikhiqiza ukungazi lutho ngokusebenza kuma-gamma aminobutyric acid subtype A (GABAA) receptors ohlelweni oluphakathi lwezinzwa (CNS). Lawa ma-receptors ayiziteshi ezinamasango e-ionotropic, futhi i-GABA iyiligand yabo yokugcina. I-GABA yi-neurotransmitter eyinhloko yokuvimbela ku-CNS. Ngemuva kokuthi i-receptor yenziwe yasebenza, isiteshi siyavula futhi sithuthukise ukwenziwa kwe-chloride esitokisini, kubangele i-hyperpolarization yolwelwesi lwe-postsynaptic. Ezingxenyeni eziphansi, i-alfaxalone iyamodareyitha i-chloride yamanje ngesiteshi se-chloride; kepha ekugxileni okuphezulu, isebenza njenge-GABA agonist, ngendlela efanayo ne-barbiturates. Umphumela wokugcina ukujula okujulile noma ukufakwa kwe-anesthesia, kuya ngomthamo nomzila wokuphatha.

 

Isicelo se-Alfaxalone

I-Alfaxalone, eyaziwa nangokuthi i-alphaxolone noma i-alphaxalone futhi esetshenziswa ngaphansi kwegama lokuhweba i-Alfaxan, iyi-neuroactive steroid kanye nomuthi ojwayelekile wokubulala izinzwa osetshenziswa ezinjeni nasemakati. Ingasetshenziswa njenge-ejenti yokungeniswa noma i-anesthesia ejwayelekile.

 

Izinzuzo nezinkinga ze-Alfaxalone

  • Izinzuzo:

I-Alfaxalone ibangela ushintsho oluncane ekuphumeni kwenhliziyo noma umfutho wegazi lapho kunikezwa imithamo efanele emitholampilo ezigulini ezinempilo. I-Alfaxalone inenkomba ephezulu yokwelapha, iyisenzo esifushane, futhi asihlanganisi. Lezi zici zenza i-alfaxalone ilungele ukusetshenziswa njenge-ejenti yokungeniswa noma yokuhlinzeka nge-anesthesia ejojoweyo.

I-Alfaxalone nayo ingahlinzekwa nge-intramuscularly, ngakho-ke ingasetshenziselwa ukuthambisa iziguli ezingasebenzisani. Lapho i-alfaxalone isetshenziselwa ukuthambisa isiguli umthamo yi-1-3mg / kg IM futhi imvamisa ilawulwa ngokubambisana ne-opioid yokuthamba okulungile.

Lapho i-alfaxalone isetshenziselwa izigaba zokubeletha imidlwane iqaphile futhi inempilo ngezikolo ezithuthukisiwe ze-AGPAR uma kuqhathaniswa nepropofol.

 

  • Okumbi:

I-Alfaxalone ibangela ukucindezelwa kokuphefumula okuxhomeke kumthamo, ne-apnea engase yenzeke kulandela umjovo we-IV osheshayo. Zilungiselele ukubhoboza intambo, unikeze ukwesekwa komoya-mpilo, futhi uvule umoya uma usebenzisa i-alfaxalone ukuthola noma ukufaka isidumbu.

Ukuphathwa ngokweqile kwe-alfaxalone kungadala ukucindezelwa kwenhliziyo okuncike emthanjeni, ngokuncipha okukhulu kukho konke ukuphuma kwenhliziyo nomfutho wegazi. Umthamo we-alfaxalone kufanele ubhalwe ngokucophelela ezigulini ezinciphise izinqolobane zenhliziyo noma ezingazinzile njenge-hemodynamically.

I-Alfaxalone ayinikeli nge-analgesia, ngakho-ke kufanele isetshenziswe ngokuhlanganyela ne-opioid efanelekile ngezinqubo ezibuhlungu.

Lapho i-alfaxalone ilawulwa nge-intramuscularly ivolumu yomjovo ingaba nkulu, engadala ubuhlungu bomjovo. Umthamo omkhulu ungenza futhi ukuphatha kube nzima uma kunefasitela elilinganiselwe lomjovo ngenxa yesimo sesineke. Ukuphathwa kwe-Alfaxalone kungahle kube nomphumela ekutholakaleni okumpofu okubonakala ngamazinga ahlukahlukene okugwedla, ukusebenzisa igama kanye / noma i-myoclonus.

 

Izikhombo

[1] UWhittem T, uPasloske KS, uHeit MV et al. (2008) I-pharmacokinetics kanye ne-pharmacodynamics ye-alfaxalone emakati ngemuva kokuphathwa okukodwa nokufakwayo okuningi kwe-Alfaxan emithamo yemitholampilo kanye neyokuhlinzwa. UJ Vet Pharmacol Ther 31 (6), 571-579.

[2] UFerre PJ, uPasloske K, uWhittem T et al. (2006) I-Plasma pharmacokinetics ye-alfaxalone ezinjeni ngemuva kwe-bolus emthanjeni ye-Alfaxan-CD. IVet Anaesth Analg 33, 229-236.

[3] UMuir W, uLerche P, uWiese A et al. (2009) Imiphumela ye-cardiorespiratory kanye ne-anesthetic yemithamo yemitholampilo ne-supraclinical ye-alfaxalone emakati. IVet Anaesth Analg 36, 42-54.

[4] Clarke KW, I-Trim CM, iHholo LW, ama-eds. (2014). "Isahluko 15: I-Anesthesia yenja". I-Anesthesia Yezilwane (11th ed.). I-Oxford: I-WB Saunders. amakhasi 135-153.

[5] UVarga M (2014). "Isahluko 4: I-Anesthesia ne-Analgesia". Incwadi Yemithi Yogwaja (2nd ed.). IButterworth-Heinemann. amakhasi 178-202.

[6] UNieuwendijk H (Mashi 2011). "Alfaxalone". I-Veterinary Anesthesia ne-Analgesia Support Group. Ibuyiswe ngoJulayi 14, 2017.

[7] UZeltzman P (Novemba 17, 2014). "Kungani Ukuphatha i-Alfaxalone Kudinga Ingcosana Yezemfundo". Izindaba Zokwenza Kwezilwane. Ibuyiswe ngoJulayi 14, 2017.