I-NMN powder - Umhlinzeki Wefektri Yomkhiqizi
I-AASraw ikhiqiza izimpushana ze-NMN ne-NRC ngobuningi!

β-Nicotinamide Mononucleotide

Isilinganiselwa: Isigaba:

I-AASraw ineziqu zokunikezela ngemikhiqizo yokulwa nokuguga-i-NMN Powder ngobuningi ngomthethonqubo we-CGMP kanye nohlelo lokulawula ikhwalithi elandelekayo. Ukukhiqizwa kwethu okuphakathi nyangazonke kungafinyelela ku-1500kg. Siyakwamukela ukuxhumana nathi ukuthola eminye imininingwane yokuthenga:
Isimo: Kusesitokweni

Amaphakheji Unit: 1kg / isikhwama, 25kg / isigubhu

Product Incazelo

Izici Eziyisisekelo

Igama Product β-Nicotinamide Mononucleotide (NMN)
CAS Inombolo 1094-61-7
Formula Yamamolekhula C11H15N2O8P
Isisindo sesisindo 334.22
omqondofana I-NMN;

β-D-NMN;

I-BETA-NMN;

i-beta-D-NMN;

I-NMN powder;

I-NMN zwitterion;

INICOTINAMIDE RIBOTIDE;

INicotinamide nucleotide;

I-nicotimide mononucleotide.

ukubukeka powder emhlophe
Isitoreji nokuphatha 2-8 ° C endaweni eyomile

Iphuzu eliyisihluthulelo:

I-NAD + i-coenzyme ebalulekile edingekayo empilweni nasemisebenzini yeselula.

♣ Amaleveli we-NAD +, ikakhulukazi ifomu lawo le-NAD +, lehla ngokwemvelo ngokukhula kwezicubu eziningi.

Body Umzimba udala i-NMN njengesinyathelo esiphakathi noma "umanduleli" we-NAD +. Kalula nje: amazinga aphezulu e-NMN asho amazinga aphezulu we-NAD +.

Kwaziwa: Kuma-athikili alandelayo, Kusetshenziswe i-NMN esikhundleni se-β-Nicotinamide Mononucleotide (NMN)


 

Ingemuva le-NMN- NAD + & NMN

I-NAD + iyinhlanganisela eyingqayizivele, eyenziwe ngokuqhubekayo emzimbeni wethu futhi isetshenziswe ngama-enzyme amaningi asemqoka ukusiza ukukhuthaza ukusebenza okuhle kwamaselula. Kodwa-ke, njengoba i-NAD + isetshenziselwe inqubo yokubhebhethekisa lezi zinhlelo ze-enzyme, siqala ukungena kokushoda kwe-NAD + ezindaweni ezahlukahlukene ezimpilweni zethu, ngokuvama okwandayo njengoba sikhula. Njengoba la ma-enzyme anikwe amandla yi-NAD + adlala indima ebalulekile ekugcineni amandla eselula, nokukhuthaza impilo yamaselula, ukwehla kwe-NAD + kungaba yingozi enkulu empilweni yethu yonke.

Ngenxa yalokhu, ucwaningo oluningi luqalisiwe ekukhuthazeni amazinga we-NAD + emzimbeni. Umbono wokukhuthaza amazinga we-NAD + ukuthi uzoba nomphumela osekela kakhulu imisebenzi eminingi ebucayi yomzimba, futhi ngalokho ungasiza ukukhuthaza impilo ende. Okubaluleke kakhulu kepha, amazinga athuthukisiwe we-NAD +, akufanele nje akhuthaze impilo ende, kungasiza futhi ukukhuthaza ikhwalithi engcono yempilo njengoba sikhula!

Ngakho-ke siphakamisa kanjani amazinga we-NAD +? Lokhu kubonakala kuyinkohliso impela. Kodwa-ke, ucwaningo lwakamuva luthole inhlanganisela eyingqayizivele ebizwa ngeNicotinamide Mononucleotide (NMN), umzimba ongayisebenzisa njengesandulela esisebenza kahle kakhulu ku-NAD +. Ngokwethiyori, lokhu kusho ukuthi i-NMN ingakhuthaza impilo ende nenempilo!

Kodwa-ke, i-NMN ayisiyo kuphela impilo ende emnandi yokukhuthaza ukwengeza. Eqinisweni, i-NMN iyisengezo esimnandi sabantu abasha nabadala, ngoba inomphumela obalulekile noma ngabe uneminyaka emingaki. Abantu abasha nabadala bobabili badinga amazinga aphezulu we-NAD + ukuze imizimba yabo nezingqondo zabo zigijime ekusebenzeni okuphezulu. Ukuphakama kwamazinga akho e-NAD +, amandla weselula ozoba nawo kakhulu, futhi umzimba wakho nengqondo yakho kuzokwazi ukusebenza ezimeni ezifuna kakhulu. Masibe neqiniso, ngubani ongakwazanga ukusebenzisa onqenqemeni oluncane kuleli zwe elisheshayo nelifuna izinto ngenkani? Ngakho-ke, uma ufuna ukukhokhisa amangqamuzana akho, futhi ufuna ukwazi ukuthi umzimba nengqondo yakho kungakufezani nge-NAD + eyengeziwe ekukhahleleni, khona-ke sizokukhuthaza ukuthi uqhubeke ufunda ngale bhulogi ebanzi kakhulu eyenzelwe ukukusiza uthole okuningi ngaphandle kwesengezo se-NMN!

 

Yini i-NMN?

I-NMN (Nicotinamide Mononucleotide) ingeyomndeni wama-nucleotide, ama-molecule e-organic atholakala kokudla okuningi esikudlayo. Njengawo wonke ama-nucleotide, i-NMN yakhiwa izingxenye ezi-3: isisekelo se-nitrogen, ushukela, neqembu le-phosphate.

Ngenkathi iningi lama-nucleotide lisetshenziselwa ukwakha i-DNA, i-NMN isetshenziselwa ukwenza i-nicotinamide adenine dinucleotide (NAD +) nokulinganisa amandla kahle. Umzimba udala i-NMN njengesinyathelo esiphakathi noma "umanduleli" ku-NAD +. Kalula nje: amazinga aphezulu e-NMN asho amazinga aphezulu we-NAD +.

I-NAD + inyusa imali eyinhloko yamandla omzimba (i-ATP), ilinganisa isigqi se-circadian, futhi inike amandla amakhulu ezinto ezenziwa nge-enzymatic - eziningi zazo ezibambezela ukuguga. Amaleveli we-NAD +, ikakhulukazi ifomu lawo le-NAD +, lehla ngokwemvelo ngokukhula kwezicubu eziningi.

 

Isebenza Kanjani i-NMN? / Kungani Udinga isengezo se-NMN?

I-NR ne-NMN zombili zizuzisa ngoba ziphakamisa amazinga e-NAD +, ancipha ngobudala. I-NAD + ibalulekile ekuguqulweni kwamaselula, kuguqula izakhi zomzimba kube amandla eselula, futhi kuphinde kusebenze ama-sirtuin, iqoqo lamaprotheni alawula impilo yamaselula. Sonke sithola i-NAD + emizimbeni yethu ngenxa yokudla kwethu, ngokudla ukudla okunezandulela ze-NAD + kuzo. Ngenkathi i-NR ne-NMN ingatholakala kumanani wokulandela ekudleni okuhlukahlukene, noma kunjalo, umuntu akanakudla okwanele kwanoma yini ukukhulisa amazinga e-NAD +. Ngenxa yalokhu, ukwengeza nge-precursor ye-NAD + kungasiza ekunciphiseni ukwehla.

 

Izinzuzo ze-NMN

  • I-NMN ikhulisa ukunikezwa kwamandla kumaseli aguga:

Amaseli ayangena futhi acubungule uphethiloli ukuze anike amandla imisebenzi yawo. Njengoba ukhula balahlekelwa yileli khono, kubaphoqa ukuthi bangene esimeni esaziwa ngokuthi yi-senescence yeselula noma ukuguga ngokwemvelo okuza neminye imiphumela emibi. I-NAD + okuyiyona nto ebalulekile ekunikezelweni kukaphethiloli weseli bekucatshangwa ukuthi ukuphela kwendlela iNMN enganikela ngayo Lokhu kusho ukuthi ukwengeza nge-NMN kunika amaseli akho indlela eshesha kakhulu yokufaka uphethiloli futhi kukhuthaze ukuhlukaniswa kwamaseli nokukhula.

 

  • I-NMN iyasiza ekulweni nezifo ze-metabolic:

Njengoba ukhula, izimo ezifana nesifo sikashukela, ukukhuluphala ngokweqile, i-dyslipidemia, nesifo sesibindi esinamafutha (i-NAFLD) siyanda. Zibangelwa ukwehla kwamazinga we-NAD +. I-NMN isebenza ngendlela ye-salvage ukuze ithuthukise amazinga e-NAD + ngaleyo ndlela yenze ngcono lezi nezinye izifo ze-metabolic.

 

  • I-NMN ivuselela ukugeleza kwegazi okuntengantengayo:

Njengoba umzimba uguga, inani nemisebenzi yamaseli endothelial (ECs) afaka imithambo yegazi ayancipha.Izandulela ze-NAD + ezifana ne-NMN ne-nicotinamide riboside (NR) esebenza nge-Sirtuin Pathway, zingasiza ekubuyiseleni amandla amaseli endothelial akha igazi elisha. izitsha.

 

  • I-NMN icindezela ukuzuza kwesisindo okuhlobene nobudala:

Njengoba abantu beguga, baba nesisindo. Ocwaningweni lwango-2016, kutholakale ukuthi izifundo ezinikezwe i-NMN zibone ukuthi amafutha azo ancipha futhi ukwanda kwesisindo esikhulu. Ngokunezela nge-NMN, ungalahlekelwa isisindo futhi wakhe imisipha — izindlela ezimbili ezinamandla zokuthuthukisa impilo yemisipha futhi ubukeke futhi uzizwe umncane!

 

  • I-NMN ikhulisa imetabolism yamandla:

Ngokulamula ukuhlanganiswa kwe-NAD +, i-NMN isiza ekwephuleni izakhi emandleni, inike amandla imisebenzi ebalulekile yamaseli futhi inciphise ukucindezeleka kwe-oxidative. Lezi zinqubo ze-biochemical zihamba kancane futhi zingamisa inqubo yokuguga. I-NMN ayikhulisi amandla akho kuphela kepha isiza ekulungiseni amaseli akho!

 

Ukuphepha kwe-NMN kanye Nemiphumela engemihle

I-NMN ithathwa njengephephile ezilwaneni, futhi imiphumela ithembisa ngokwanele ukuthi ukuhlolwa kwabantu sekuqalile. Le molekyuli kubhekwe kakhulu ukuthi iphephile futhi ayinabuthi, ngisho nasezingxenyeni eziphezulu kumagundane nasesifundweni somuntu. Ukuphathwa ngomlomo kwesikhathi eside (unyaka owodwa) kumagundane akunayo imiphumela enobuthi. Isivivinyo sokuqala somtholampilo kubantu saqedwa futhi ubufakazi buxhasa umbono wokuthi akuyona into enobuthi ngemithamo eyodwa.

Yize ucwaningo olulodwa lwamadoda aseJapan olushicilelwe ngoNovemba 2019 luthi izifundo zazinyuse amazinga e-bilirubin egazini labo kulandela ukuphathwa kwe-NMN, lawa mazinga ahlala ebangeni elijwayelekile. Ucwaningo lwesikhathi esizayo kufanele lubheke ekuphepheni kwesikhathi eside nasekusebenziseni ukusetshenziswa. I-NMN ayihlotshaniswa neminye imiphumela emibi eyaziwayo.

 

I-NMN njenge-NAD + Supplement-Idume kakhulu

Ukugxilwa kwe-Intracellular kwe-NAD + kwehla kusukela ekugugeni njengoba imisebenzi ejwayelekile yeselula iqeda ukunikezwa kwe-NAD + ngokuhamba kwesikhathi. Amazinga aphilile we-NAD + kucatshangwa ukuthi abuyiselwa ngokuxhaswa nge-NAD + precursors. Ngokuya ngocwaningo, izandulela ezifana ne-NMN kanye ne-nicotinamide riboside (NR) zibhekwa njengezengezo zokukhiqizwa kwe-NAD +, okwandisa ukugxila kwe-NAD +. UDavid Sinclair, umcwaningi we-NAD + waseHarvard, uthi, “Ukondla noma ukufaka i-NAD + ngqo ezintweni eziphilayo akuyona into esebenzayo. I-molecule ye-NAD + ayikwazi ukuwela kalula ulwelwesi lweseli ukungena kumaseli, ngakho-ke ngeke itholakale ukuze ithinte kahle imetabolism. Esikhundleni salokho, ama-molecule angaphambi kwe-NAD + kufanele asetshenziselwe ukukhulisa amazinga angatholakali e-NAD +. ” Lokhu kusho ukuthi i-NAD + ayinakusetshenziswa njengesengezo esiqondile, ngoba ayisitholi kalula. Izandulela ze-NAD + zithathwa kalula kune-NAD + futhi zisebenza kahle kakhulu.

 

Kufanele Ukwazi Ngaphambi Kokuthenga I-NMN Powder Online

 

Structure Isakhiwo esingazinzile.

Isizukulwane sokuqala se-NMN esinobuningi obuphansi besingenakho uketshezi oluhle kakhulu. Uhlobo oluthuthukisiwe lwe-AASraw lweNMN luzokwehlisa izindleko zokukhiqiza ngokuhamba okungcono kwe-powder okuholela ekwandeni komthamo wokukhiqiza njengoba kuzoba lula ukuqhuba ngemishini. Ngaphezu kwalokho, le nguqulo izoholela kumthamo ofanayo wamaphilisi njengoba inguqulo yesisindo esiphansi kunzima ukuyihlanganisa ngokufana. Okokugcina, i-powder ephansi ye-NMN ecindezelwe kwifomu yethebhulethi ingahlakazeka kalula ngesikhathi sokuhamba.

Amaklayenti amaningi azama ukuxazulula lokhu ngokunezela izithasiselo kepha lokho kuholela kumathebulethi amakhulu, angahambisani kahle nabathengi kubantu ababekiwe. Ngakho-ke, ukuminyana okuphansi kwe-NMN kufaneleke kuphela ekwakhiweni komkhiqizo we-powder.

 

Ingredients Izithako ze-NMN ezigcwele ngaphakathi.

Ngeshwa imakethe igcwele i-NMN mbumbulu. Kusukela i-NMN yangena emakethe ngonyaka odlule izinhlobo eziningi ezintsha ze-NMN zivele zilandelana. Kunzima kakhulu kubakhiqizi namakhasimende ethu ukutshela izinto zangempela ezisezingeni eliphakeme ezivela kuzithako ezingekho emthethweni nezingahlanzekile ezithengiswa online.

Eminye imikhiqizo yeNMN ethengiswayo inobumsulwa obungaphansi kuka-80%. Amaklayenti namakhasimende abazi nje ukuthi yini okugcwalisa noma ukungcola okukhona komunye u-20% womkhiqizo.

Sithole ukuthi abahlinzeki abaningi be-NMN bathengisa i-nicotinamide (uvithamini B3 ovamile oshibhile) noma i-nicotinamide riboside esikhundleni se-NMN. Abaphakeli abengeziwe bengeza ufulawa ukuze banciphise i-NMN futhi bakhohlise amaklayenti abo. Le mikhiqizo imvamisa ishibhile kepha futhi ayinayo imiphumela emihle.

 

▲ Ukuntuleka kokuphepha nedatha esebenza kahle.

I-NMN iya ngokuya ithandwa kakhulu e-US, Europe, Japan nase China, njll, kepha ukuphepha okuningi nemininingwane esebenza kahle kusashoda. Abantu abaningi abasathembi lo mkhiqizo, ngakho-ke imakethe yeNMN ihlala ikhawulelwe. Empeleni i-NMN ekuqaleni ikhona emzimbeni womuntu kanye nemifino efana ne-broccoli, ngakho-ke ayinazinkinga zokuphepha. Kepha yisikhathi esiphezulu sedatha eqhubeka nokuqinisekisa ukusebenza kwayo.

 

Izikhombo

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[2] UStipp D (Mashi 11, 2015). "Beyond Resveratrol: I-Anti-Aging NAD Fad". Inethiwekhi Yesayensi YamaMelika.

[3] ICambronne XA, iKraus WL (Okthoba 2020). "+ Synthesis kanye nemisebenzi Amaseli Mammalian". Amathrendi ku-Biochemical Sciences. 45 (10): 858-873. i-doi: 10.1016 / j.tibs.2020.05.010. PMC 7502477. PMID 32595066.

[4] UBogan KL, uBrenner C (2008). "I-Nicotinic acid, i-nicotinamide, ne-nicotinamide riboside: ukuhlolwa kwamangqamuzana ama-NAD + amavithamini angaphambi kokudla komuntu". Ukubuyekezwa Kwaminyaka Yonke Kwezomsoco. 28: 115-30. i-doi: 10.1146 / annurev.nutr.28.061807.155443. I-PMID 18429699.

[5] Yue Yang, Anthony A. Sauve. I-NAD + metabolism: Bioenergetics, signaling and manipulation for therapy. I-Biochim Biophys Acta, 2016; INGXENYE: 10.1016 / j.bbapap.2016.06.014.

[6] Izigayo KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Ukuphathwa Kwesikhathi Eside kweNicotinamide Mononucleotide Kunciphisa Ukwehla Kwemvelo Okuhambisana Nobudala Emagundeni. Iseli Metab, 2016; INGXENYE: 10.1016 / j.cmet.2016.09.013.

[7] UNiels J. Connell, uRiekelt H. Houtkooper, uPatrick Schrauwen. I-NAD + metabolism njengelitshe lempilo ye-metabolic: siyitholile yini inhlamvu yesiliva? Isifo sikashukela, 2019; INGXENYE: 10.1007 / s00125-019-4831-3.

[8] U-Ann Katrin-Hopp, uPatrick Grüter, uMichael O. Hottiger. Ukulawulwa kweGlucose Metabolism yi-NAD + ne-ADP-Ribosylation. Amaseli, 2019; I-DOI: 10.3390 / amaseli8080890.

[9] UShuang Zhou, uXiaoqiang Tang, uHou-Zao Chen. Ama-Sirtuins nokuphikiswa kwe-Insulin. Ngaphambili Endocrinol (Lausanne), 2018; INGXENYE: 10.3389 / fendo.2018.00748.