I-Nootropic Coluracetam: Ungasebenza Kanjani Ebuchosheni Futhi Uphathe Ukukhathazeka
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I-Coluracetam

Umndeni WeRacetam weNootropic– I-Coluracetam

IColuracetam (BCI-540, noma iMKC-231) iyi-nootropic encibilikayo enamafutha esigabeni sama-racetam. IColuracetam inamandla kakhulu kune-racetam yasekuqaleni, I-Piracetam. IColuracetam yayinegunya lobunikazi yi-Mitsubishi Tanabe Pharma yaseJapan ngonyaka ka-2005. Iyenza enye yama-nootropiki amasha asekelwe ku-racetam.

I-patent yeColuracetam yathengiswa kamuva kwaBrainCells, Inc. eSan Diego, California. I-BrainCells iyinkampani encane, ephethwe ngasese ephethe i-biopharmaceutical egxile ekwakhiweni kwamakhemikhali okwelashwa kwesifo esikhulu sokudangala (MDD), ukucindezelwa okungazweli ekwelashweni (TRD), kanye ne-Alzheimer's's Disease.

IColuracetam iyefana ngesakhiwo nePiracetam. Futhi njengawo wonke ama-nootropics e-racetam, ane-pyrrolidone nucleus emgodleni wayo. Ucwaningo lwakamuva lomtholampilo lukhombisa ukuthi kungenzeka yini ukwelapha ukuphazamiseka kwengcindezi, kanye nokulimala kwezinzwa kwe-retinal ne-optic.

IColuracetam inamandla kakhulu i-choline ekhomba ama-supplement. Ikhulisa ukuguqulwa kwengqondo yakho ye-choline ibe yi-acetylcholine (ACh) ngenqubo yokutholwa kwe-choline (HACU) ephezulu. Okukhulisa ukuqapha, ukunaka imininingwane nememori.

Olunye ucwaningo, nokuhlangenwe nakho komuntu siqu kubonisa ukuthi iColuracetam ingathinta ama-AMPA receptors. Kwenza i-nootropic ye-ampakine engahle ibe khona. Okungachaza imiphumela efana nevuselelayo ngaphandle kwemiphumela emibi yezikhuthazi zendabuko. IColuracetam iphinde ikhombise ezinye zezimfanelo ze-anxiolytic (anti-anxiety) ezisiza ukuthuthukisa imizwa nokuthula ukukhathazeka.

 

Kanjani Ci-erracetam Works(Indlela Yokusebenza)

Njengamakhemikhali amaningi e-racetam, i-coluracetam (i-CAS:135463-81-9) isebenza ikakhulu ngokwanda kwamazinga e-neurotransmitter acetylcholine, ehlobene kakhulu nokufunda, inkumbulo nokuqonda.

Kodwa-ke, indlela i-coluracetam eguqula ngayo amazinga e-acetylcholine ihlukile. Imvamisa, ama-racetam aqala ukukhiqizwa kwe-acetylcholine ngokushukumisa ama-receptors afanele, kepha i-coluracetam ikwenza lokho ngokuthuthukisa ukutholwa okuphezulu kwe-choline, noma i-HACU. Uhlelo lwe-HACU lunquma isilinganiso lapho i-choline idonswa kuma-neurons ukuze iguqulwe ibe yi-acetylcholine.

Ngokwandisa isilinganiso lapho i-choline idonselwa kumaseli ezinzwa, i-coluracetam igqugquzela ukukhiqizwa kwe-acetylcholine futhi ibangele ukuthi amazinga obuchopho ale-neurotransmitter ebalulekile akhuphuke. ukutholakala okusheshayo kwe-choline ukuze kuthathwe.

Ngokubambisana lezi zenzo ziholela emazingeni aphezulu e-acetylcholine, ahlotshaniswa nokuqonda okuthuthukisiwe nenkumbulo.

I-Coluracetam

Izinzuzo Futhi Effects Of I-Coluracetam

 IColuracetam Ithuthukisa Inkumbulo Nokufunda

Izinzuzo zeColuracetam zifakazela ukuthi zisebenza ekuphoqeleleni umsebenzi wokuqonda nokukhumbula kumagundane nemiphumela efanayo kubantu. AbakwaBrain Cells Inc. benze ucwaningo oluveza ukuthuthuka kwengqondo kumagundane ngemuva kokuthola i-AF64A izinsuku eziyisishiyagalombili. Ukuthuthukiswa kwaqhubeka ukuhlala ngisho nangaphandle kokwelashwa. Isifo i-Alzheimer kuholela emazingeni aphansi e-acetylcholine. Ngokukhula kwe-acetylcholine ku-hippocampus, i-coluracetam izokhulisa izimpawu zesifo i-Alzheimer njengokuphazamiseka kokufunda nenkumbulo embi.

 

 IColuracetam Yehlisa Ukudangala Okumelana Nokwelashwa

Ekucwaningeni kwabantu abayi-101 abanokucindezeleka, abangazange bathole ukwelashwa komphumela ngama-anti-depressants, kube nomthelela owakhayo ekwenzeni ngcono izinga lempilo ngama-80 mg kathathu ngosuku. Kodwa-ke, lesi yisifundo kuphela esenziwa ngabantu. Amandla aphethwe ukunciphisa i-glutamate noxiousness angaba nesibopho semithelela yawo emihle ekwelashweni kokudangala.

 

 IColuracetam Yehlisa Ukukhathazeka

Esifundweni segundane, ukulinganisa izinsuku ezingama-21 ze-coluracetam kukhombisa ukuthuthuka okungama-20% ekukhathazekeni, obekuphakeme kunomthelela we-12% wethonya le-valium kumthamo owodwa esifundweni esifanayo.

 

 I-Coluracetam Iphromotha i-Neurogeneis

Olunye ucwaningo luthi luyasiza nge-neurogeneis. Indlela eyinhloko ayikacaci, kepha ihlobene nokuphathwa kwayo amasonto ambalwa, okwanda ku-acetylcholine endaweni ye-hippocampus. '' Amalungelo obunikazi athi akhuthaza ukukhula kwamangqamuzana ezinzwa (neurogenesis). Lo mshini awaziwa, kepha kucatshangwa ukuthi uhlobene nokwanda kwe-hippocampal acetylcholine lapho i-coluracetam idonswa nsuku zonke amasonto ambalwa. ''

 

 I-Coluracetam Isiza ngeSchizophrenia

IColuracetam inyusa umsebenzi we-CHAT kumagundane onomonakalo weseli yezinzwa. Lokhu kwanda kuphakamisa ukuthi kungazuzisa iziguli ezine-schizophrenia ngokusebenzisa le enzyme efanayo. Ucwaningo oluningi ngqo kubantu abane-schizophrenia luyaqhubeka.

 

 I-Coluracetam Kuthuthukisa Ukubona

IColuracetam ikhombise amandla ayo we-optic njengokuqashelwa kombala okuthuthukisiwe, ukubona, nokucaca. Ngokuqondile, ithuthukisa ukukhula kwemizwa yesifo esiwohlozayo se-retinal. Izifundo eziningi zisho ukubona kangcono umbala nokucija kwamehlo, kepha alukho ucwaningo lwesayensi oluye lwaqinisekisa le miphumela.

I-AASraw ingumkhiqizi oqeqeshiwe weColuracetam.

Sicela uchofoze lapha ukuthola ulwazi lwesilinganiso: Oxhumana nathi

 

Isebenza kanjani iColuracetam ebuchosheni?

IColuracetam ikhulisa impilo yobuchopho nokusebenza ngezindlela eziningi. Kepha ababili ikakhulukazi bavelele.

IColuracetam ikhulisa ubuchopho bakho'Ukuthathwa kwe-choline ngokukhomba nokusebenza nenqubo ephakeme yokuhlangana kwe-choline (HACU) kuma-neuron obuchopho.

I-Acetylcholine (ACh) yakhiwe nge-choline ne-acetate. Lokhu kumele kutholakale esikhungweni se-neuron ngaso sonke isikhathi. Ukuze i-ACh ihlanganiswe noma nini lapho idingeka.

I-choline yamahhala ejikeleza egazini yeqa isithiyo segazi nobuchopho. Futhi ithathwa ngamatheminali e-cholinergic neuron. Iyangena ku-neuron ngohlelo oluphezulu lwe-choline uptake (HACU). Ukuhlanganiswa kwe-ACh kwenzeka emgodini we-synaptic. Isikhala esiphakathi kwama-neurons njengoba sihamba siye ku-neuron.

Uhlelo lwe-HACU luthembele ekushiseni-, emandleni- nase-sodium. Lolu hlelo luyizindlela eziyinhloko lapho i-choline edingekayo ekuhlanganisweni kwe-ACh ithunyelwa ku-neuron. Futhi isinyathelo esinciphisa izinga ekukhiqizeni le neurotransmitter ebucayi.Uma lolu hlelo luphela noma lungasebenzi kahle njengoba lwenzelwe, uba nezinkinga ngememori, ukufunda, nenkungu yobuchopho.

I-Coluracetam inemiphumela kule nqubo futhi iyisiza ukuthi isebenze kahle. Eqinisweni, kubonakala ngathi kukhulisa inqubo ye-HACU. Ngisho nakuma-neurons awonakele. Ukwandiswa kwe-acetylcholine kuma-neurons kusiza ukuthuthukisa inkumbulo, kuqinisa ukuqonda futhi inikezela ngamakhono angcono okwenza izinqumo.

IColuracetam nayo ibonakala ithuthukisa amandla we-AMPA. Ama-receptors e-AMPA athinteka yi-glutamate. Okusebenza ebuchosheni nasenkabeni yezinzwa ukwenza ngcono ukuqapha nokuqonda.

IColuracetam isebenza ngokubili kokuqina kwe-AMPA kanye nokuthuthukiswa kokutholwa kwe-choline. Le nhlanganisela ibonakala isiza ukuthuthukisa ukuphazamiseka kwemizwelo ngaphandle kokuthinta amazinga e-serotonin.

ISerotonin Selective Reuptake Inhibitors (i-SSRIs) yindlela yezokwelapha ejwayelekile ekhethiwe yokubhekana nokuphazamiseka kwemizwelo nokudangala. Bafika nohlu lwemiphumela emibi eyingozi. Futhi ungasebenzeli zonke iziguli ezicindezelekile.

Abaphenyi babike ukuthi iColuracetam ibilusizo ekwelapheni ukucindezeleka okukhulu komtholampilo nokukhathazeka kokukhathazeka. Ngaphandle kokuthinta amazinga e-serotonin ebuchosheni. Futhi ngaphandle kwemiphumela emibi ehambisana nokuphazamisa i-serotonin.

I-Coluracetam

I-Coluracetam Ukusetshenziswa: Isilinganiso Nesitaki Sereferensi Kuphela

IColuracetam iyinhlanganisela engatholakali kunoma yikuphi ukudla futhi imizimba yethu ayikwazi ukukhiqiza. Ngakho-ke, okuwukuphela kwendlela yokuveza izinzuzo zale molecule kungokwengeza.

IColuracetam imvamisa ithengiswa ngefomu le-powder noma le-capsule futhi ingathathwa ngomlomo. Imithamo nayo ingathathwa ngokuncanyana (ngaphansi kolimi) ukumuncwa ngokushesha nangokushesha.

Njengoba i-coluracetam ingumenzeli onamandla kakhulu, kungakuhle ukuthi uqale ngomthamo womphumela ophansi kakhulu. Uma uthola ukuthi udinga ukwandisa umthamo ukuze uzwe izinzuzo, lokhu kufanele kwenziwe kancane kancane futhi akufanele kudlule u-80mg.

I-Coluracetam ayinabuthi futhi ibhekwa njengephephile futhi ibekezeleleka kahle.Imiphumela engemihle embalwa kuphela engahlobene nale nhlanganisela, njengokukhathazeka, ikhanda elibuhlungu, ukukhathala kanye nesicanucanu. Le miphumela emibi ayivamile futhi imane yenzeke kuphela uma kungekho echibini elikhulu elandulelayo le-choline elizosetshenziselwa ukuhlanganiswa kwe-acetylcholine. Yingakho sincoma ukuqala i-coluracetam yokuqamba-yokwengeza ngezinga le-choline elithuthukisa njenge-citicoline.

IColuracetam ingaxhumana nezinye izidakamizwa, ikakhulukazi lezo ezihlangana ne-NMDA receptor. Lokhu kufaka phakathi ukucindezela ukukhwehlela kanye ne-anesthetics. Ezinye izinto ezihlangana nohlelo lwe-cholinergic, njengemithi ye-glaucoma ne-nicotine, nazo zingaxhumana nemiphumela ye-coluracetam. IColuracetam ingamelana nemiphumela yemithi elwa ne-cholinergic (efana neBenadryl, amanye ama-antipsychotic kanye nemithi kaParkinson).

Njenganoma yikuphi ukwengeza, uma unemithi noma unesimo sempilo esiyisisekelo, kunengqondo ukuthi ukhulume nodokotela wakho ngaphambi kokuqala noma yikuphi ukwengeza umbuso.

 

 How To Lezitaki Wyena With Ezinye Izidakamizwa

♦ IColuracetam iyimolekyuli encibilikiswa ngamafutha, ngakho-ke kungcono kakhulu ukufakwa ngamafutha anempilo njengokakhukhunathi noma uwoyela we-MCT.

♦ IColuracetam kufanele futhi ifakwe isitaki se- isengezo se-choline njenge-citicoline. I-Citicoline inyusa ichibi le-choline etholakalayo yokuhlanganiswa. Isitaki singadala imiphumela enamandla ngokwandisa i-choline (citicoline) kanye nekhono lokuyihlanganisa ibe yi-acetylcholine (coluracetam).

 

 Umthamo onconyiwe: 5-80mg ngosuku

Sincoma phakathi kuka-5-80mg we-coluracetam ngosuku.

Umkhawulo ophephile ophezulu we-coluracetam ngu-80mg ngosuku. Kodwa-ke, sincoma ukuhlala ne-35mg ngosuku njengoba imiphumela yamanani aphezulu engakahlolwa ngokuphelele kubantu.

Kulungile ukuhlukanisa lezi zilinganiso zibe ngumthamo ekuseni noma ntambama. Isibonelo, umthamo we-20mg we-10mg ekuseni kanye no-10mg owengeziwe ntambama.

Njengoba kushiwo ngaphambili, kufanele uqale ekugcineni okuphansi kwesikali sokulinganisa. Ukuqala komthamo osebenza kahle kakhulu kuzonciphisa amathuba okuba nemiphumela emibi.

 

Imiphumela emibi ye-Coluracetam

IColuracetam ayinabuthi. Ngakho-ke kubhekwa ukubekezelelwa kahle futhi kuphephile. Abasebenzisi abaningi bokuqala be-Coluracetam babika ukukhathala okuvame ukuba ngumphumela wokuqala ngomthamo ophakeme kakhulu.

Khumbula, iColuracetam isebenza ngokwandisa ukutholwa kwe-choline ebuchosheni bakho. I-Choline iyisandulela sokukhiqizwa kwe-acetylcholine. Uma ingekho i-choline eyanele ohlelweni lwakho, uzozwa imiphumela emibi.

Imiphumela emibi ayifani kodwa ingafaka ukukhathazeka, ukukhathala, ikhanda, ukwethuka nokucabangela. Futhi, imiphumela emibi ngokuvamile iwumphumela wokulinganisa okungavamile kwe-nootropic.

Ukuphathwa yikhanda ekusebenziseni iColuracetam kwenzeka kakhulu uma ukhohlwa ukuyihlanganisa nesengezo esihle se-choline. Ukuphathwa ikhanda ngokuvamile kuyisibonakaliso sokushoda kwe-choline ebuchosheni bakho.

 

Ukubuka konke– I-Coluracetam

IColuracetam ingelinye lamalungu amasha angajwayelekile kakhulu esigabeni se-racetam se ama-nootropics, kepha kuyintandokazi kubasebenzisi abaningi.

Kwandisa amazinga e-acetylcholine `` yokufunda i-neurotransmitter '', engahle ikhulise ukuqonda, futhi ucwaningo lwezilwane lukhombisa ukuthi lungaqeda ukusilela kwememori ngaphandle kwemiphumela emibi. Yize kunocwaningo lomuntu oluncane olunamakhompiyutha olwenziwe nge-coluracetam, izifundo ezikhona zikhombisa ukuthi kungaba ukwelashwa okubalulekile kokukhathazeka nokudangala.

Abasebenzisi abaningi bathembela kukho njengokhuphula imizwa ethembekile nesithuthukisi sememori esibanikeza ukugxila okungcono nokugxila. Abanye bathi ibanikeza okulingana ne- "HD vision", okwenza imibala icace, iqhathanise kakhulu, futhi izibani zikhanye kakhulu.

IColuracetam iyinhlanganisela enamandla, ngakho-ke amanani esilinganiso aphansi, futhi kwaziwa ukuthi isebenza ngokushesha. Kuthengiswa njengokudla ukwengeza e-US futhi ingangeniswa ngokusemthethweni eCanada nase-UK ngamanani amancane.

Kuningi okusamele kufundwe mayelana ne-coluracetam, kepha kubonakala kuphephile kubasebenzisi abaningi lapho kuthathwe ngokuziphendulela. Uma unentshisekelo yokwengeza okuthile okusha nokuhlukile kokukodwa kwe- isitaki se-nootropic, i-coluracetam kungaba yinto okufanele uyicabangele.

IColuracetam ayinalo ucwaningo oluningi, izifundo ezitholakalayo zikhombisa amandla amakhulu okusetshenziswa kwayo. Ingenye yama-racetams asanda kwedlula, ahambisana no I-Fasoracetam. Kodwa-ke, muva nje, i-FDA igunyaze ifomu "elithuthukisiwe" leFasoracetam ekwelashweni kwe-ADHD.

I-AASraw ingumkhiqizi oqeqeshiwe weColuracetam.

Sicela uchofoze lapha ukuthola ulwazi lwesilinganiso: Oxhumana nathi

 

Izikhombo

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[2] UMurai S., Saito H., Abe E., Masuda Y., Odashima J., Itoh T. "I-MKC-231, i-choline yokuthwebula isithuthukisi, ithuthukisa ukusilela kwenkumbulo yokusebenza futhi yehlise i-hippocampal acetylcholine eyenziwe yi-ethylcholine aziridinium ion kumagundane." Ijenali Yesigaba Esijwayelekile Sokudluliswa Kwe-Neural. 1994; 98 (1): 1-13.

[3] Takashina K., Bessho T., Mori R., Eguchi J., Saito K. "MKC-231, a choline uptake enhancer: (2) Umphumela ekuhlanganisweni nasekukhishweni kwe-acetylcholine kumagundane aphathwe yi-AF64A." Ijenali ye-Neural Transmission (iVienna). 2008 Julayi; 115 (7): 1027-35.

[4] UBessho T., Takashina K., Eguchi J., Komatsu T., Saito K. "MKC-231, isithuthukisi se-choline-uptake: (1) ukuthuthuka okuhlala isikhathi eside kwengqondo ngemuva kokuphathwa okuphindaphindiwe kumagundane aphethwe yi-AF64A." Ijenali ye-Neural Transmission (iVienna). 2008 Julayi; 115 (7): 1019-25.

[5] U-Akaike A., Maeda T., Kaneko S., Tamura Y. "Umphumela wokuvikela we-MKC-231, inoveli ephezulu yokuhlangana kwe-choline ethola isithuthukisi, kwi-glutamate cytotoxicity kuma-cortical neurons akhulisiwe." Ijenali yaseJapan Yezemithi. 1998 uFebhu; 76 (2): 219-22

[6] UShirayama Y, Yamamoto A, Nishimura T, Katayama S, Kawahara R (Septhemba 2007). "Ukuchayeka okulandelayo kwe-choline uptake enhancer MKC-231 kuphikisana nokushoda kokuziphatha okubangelwa yi-phencyclidine nokunciphisa ama-septal cholinergic neurons kumagundane". I-European Neuropsychopharmacology. 17 (9): 616-26.

[7] Izibonelelo Zephrojekthi Yokuthola Ukwelashwa Efanelekayo Yombuso waseCalifornia, IRS.gov

[8] UMalkhkh, AG, noSadaie, MR (2010). I-Piracetam ne-Piracetam-Like Izidakamizwa. Izidakamizwa, 70 (3), 287-312.

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