Ividiyo ye-Pregabalin powder

 

 

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Izinhlamvu Eziyisisekelo

Igama Product:	I-Pregabalin powder
Inombolo ye-CAS:	148553-50-8
Formula Yamamolekhula:	C8H17NO2
Isisindo somzimba:	159.23
I-Melt Point:	I-194-196 ° C
Umbala:	Impushana yekristalu emhlophe noma evaliwe
Isitoreji Sokugcina:	RT

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Pregabalin Powder Izibuyekezo

I-Pregabalin powder iyimpushana emhlophe esetshenziswa njengesidakamizwa esilwa nesithuthwane, esibizwa nangokuthi i-anticonvulsant. Isebenza ngokunciphisa ama-impulses ebuchosheni abangela ukuquleka. I-Pregabalin powder iphinde ithinte amakhemikhali asebuchosheni athumela izimpawu zobuhlungu ohlelweni lwezinzwa.

I-Pregabalin powder isetshenziselwa ukwelapha ubuhlungu obubangelwa i-fibromyalgia, noma ubuhlungu bezinzwa kubantu abanesifo sikashukela (i-diabetic neuropathy), i-herpes zoster (i-post-herpetic neuralgia), noma ukulimala komgogodla.

I-Pregabalin powder iphinde isetshenziswe neminye imithi yokwelapha ukuthunjwa kokuqala okuyingxenye kubantu abadala kanye nezingane okungenani izinyanga ezingu-1. I-Pregabalin powder eluhlaza ingase isetshenziselwe izinhloso ezingabaliwe kulo mhlahlandlela wemithi.

 

I-Pregabalin Mechanism of Action

I-Pregabalin iyisidakamizwa se-anticonvulsant esisetshenziselwa ukwelapha izimo zobuhlungu be-neuropathic kanye ne-fibromyalgia, kanye nokwelapha ukuqubuka kancane kancane kuhlanganiswe namanye ama-anticonvulsants.

Nakuba indlela yokusebenza ingacaciswanga ngokugcwele, izifundo ezihilela izidakamizwa ezihlobene nesakhiwo ziphakamisa ukuthi ukubophezela kwe-presynaptic kwe-pregabalin eziteshini ze-calcium ezine-voltage-gated kuyisihluthulelo semiphumela yokulwa ne-antiseizure kanye ne-antinociceptive ebonwa kumamodeli ezilwane.

Ngokubopha i-presynaptically ku-alpha2-delta subunit yeziteshi ze-calcium ezine-voltage-gated ohlelweni lwezinzwa olumaphakathi, i-pregabalin ilungisa ukukhululwa kwama-neurotransmitters amaningana ajabulisayo ahlanganisa i-glutamate, i-substance-P, i-norepinephrine, ne-peptide ehlobene ne-calcitonin gene.Ngaphezu kwalokho, i-pregabalin ivimbela i-alpha2-delta subunit kusukela ekuhwebeni kusukela ku-ganglia yempande yomgogodla kuya ophondweni lomgogodla womgogodla, okungase futhi kube nomthelela endleleni yokusebenza. Nakuba i-pregabalin iwukuphuma kwesakhiwo kwe-gamma-aminobutyric acid (GABA) ye-neurotransmitter evimbelayo, ayibophezeli ngokuqondile ku-GABA noma kuma-benzodiazepine receptors.

 

Isebenzisa/Isicelo ePregabalin

❶ Ukusebenza kahle kwe-Pharmacological: I-Pregabalin iyinoveliγ-aminobutyric acid (GABA) receptor agonist, ingavimba iziteshi ze-calcium ezincike ku-voltage ukunciphisa ukukhululwa kwe-neurotransmitter.

❷ Umtholampilo oyinhloko wokwelapha ubuhlungu be-peripheral neuropathic kanye nengxenye yokwelashwa kwe-adjuvant of focal seizures.

❸ Ukwelashwa kwesithuthwane ekukhiqizeni umuthi othembisa kakhulu ekwelapheni umuthi ongcono futhi okahle. Ingase futhi isetshenziselwe ukwelapha ubuhlungu nokukhathazeka.

 

Imiphumela emibi ye-Pregabalin

Njengemithi eminingi, i-Lyrica ingabangela imiphumela engemihle noma emibi kakhulu. Lolu akulona uhlu oluphelele lwemiphumela engemihle futhi eminye ingase yenzeke. Umhlinzeki wezempilo angakweluleka ngemiphumela engemihle. Uma uhlangabezana neminye imiphumela, xhumana nosokhemisi wakho noma umhlinzeki wezempilo.

 

Imiphumela Ejwayelekile Ejwayelekile

Ungase ube nemiphumela engemihle ngenkathi uthatha i-pregabalin. Imiphumela emibi evamile ye-pregabalin ihlanganisa:

▪ isiyezi

▪ ukozela

▪ ukudideka

▪ ukungaboni kahle

▪ ukundindizela

▪ ukungazinzi lapho uhamba

▪ ukukhuluphala

▪ ukuqunjelwa

▪ umlomo owomile.

 

Imiphumela Emibi Ebi

Shayela umhlinzeki wakho ngokushesha uma unemiphumela emibi kakhulu. Shayela u-911 uma izimpawu zakho zizwa zisongela ukuphila noma uma ucabanga ukuthi unesimo esiphuthumayo sezokwelapha. Imiphumela emibi kakhulu nezimpawu zayo zingabandakanya lokhu okulandelayo:

▪ Imicabango yokuzibulala noma ukuzama ukuzibulala: Izimpawu zingase zihlanganise ukuzama ukuzibulala, ukukhathazeka okusha noma okwandayo noma ukucindezeleka, ukungalali kahle, ukuyaluza, ukwenza ngokuvumelana nezifiso eziyingozi kanye noshintsho olungavamile lwesimo noma ukuziphatha.

▪ Ukungezwani komzimba kakhulu: Izimpawu zingase zihlanganisa ukuphefumula kanzima, ukuqunjelwa, ukuvuvukala kolimi, izindebe, umlomo noma umphimbo.

▪ Izinkinga zenhliziyo

▪ Izinkinga ezinkulu zokuphefumula

Eminye imiphumela engemihle ingase ibe ngcono ngokuhamba kwesikhathi, kuyilapho eminye efana nesiyezi nokozela ingase ihlale inqobo nje uma uphuza umuthi.

 

Pregabalin Storage

Abantu kufanele bagcine le mithi endaweni yokushisa yegumbi elawulwayo, cishe ama-degree angu-68 kuya ku-77 degrees Fahrenheit.

Uma uhamba, hlala uphethe imithi yakho futhi ugcine ibhodlela langempela elibhalwe incwadi kadokotela noma ibhokisi esikhwameni sakho ogibela naso. Ungashiyi le mithi emotweni yakho, ikakhulukazi emazingeni okushisa abandayo kakhulu noma ashisayo.

 

Umhlahlandlela Wokuthenga I-Pregabalin Powder kusuka ku-AASraw isinyathelo ngesinyathelo

♦ Vakashela iwebhusayithi ye-AAS, khetha i-pregabalin powder oyifunayo, bese ushiya othintana naye kanye nomlayezo kusayithi le-AAS, bese uthumela,Isevisi Yekhasimende ye-AAS izokuphendula emahoreni angu-12 uma ithole umlayezo wakho, bese ukhuluma ngemininingwane.

♦ Vele uthumele i-imeyili noma uthumele imilayezo ku-whatsapp kubantu abasebenza e-AAS futhi ubatshele ukuthi ufuna ukuthenga i-pregabalin powder kusuka ku-aasraw, bese ukhuluma ngokuningiliziwe, mayelana nokuhlanzeka, inani, Ukuthumela, ikheli, ukukhetha inkokhelo efanelekile, impahla ingaba ithunyelwe kungakapheli amahora ayi-12 ngemuva kokukhokha, ngemuva kokukhokha, uzothola inombolo yokulandelela, futhi isevisi yamakhasimende ye-AAS izokugcina unolwazi ngesikhathi, lapho-ke udinga nje ukuhlala phansi ngokunethezeka, ulinde iphasela lakho.

♦ I-AAS bekuyinkampani yase-china, Ukuze uphephe, uma unomngane e-China, ungavumela abangani bakho ukuthi bavakashele inkampani yabo, baxoxe ngemininingwane, futhi bathole izimpahla ozifunayo.

 

Izikhombo

[1] Dworkin RH, O'Connor AB, Backonja M, et al. Ukuphathwa kwe-Pharmacologic yobuhlungu be-neuropathic: izincomo ezisekelwe ebufakazini. Ubuhlungu 2007;132:237-51.

[2] I-Finnerup NB, i-Jensen TS. Ukusetshenziswa komtholampilo kwe-pregabalin ekulawuleni ubuhlungu obuphakathi kwe-neuropathic. I-Neuropsychiatric Disease and Treatment 2007; 3:885-91.

[3] Kalso E, Aldington DJ, Moore RA. Izidakamizwa zobuhlungu be-neuropathic. I-BMJ 2013;347:f7339.

[4] Mannix, Liam (Disemba 18, 2018). “Lesi sidakamizwa esidumile sihlobene nokulutheka nokuzibulala. Kungani odokotela belokhu beyiyalela?” ICanberra Times. Kufakwe kungobo yomlando kusukela kokwangempela ngomhla ka-Disemba 18, 2018. Kubuyiswe ngomhla ka-Disemba 18, 2018.

[5] Noma kunjalo, uJames W.; Willmore, James; Brumback, Roger A. (2009). Ukwelapha Okuthuthukile Kwesithuthwane. PMPH-USA. p. 302. ISBN 978-1-60795-004-2.

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