I-Lorcaserin HCL powder (1431697-94-7) hplc =99% | Ukulahlekelwa Ukulahlekelwa Kwemvelo
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I-Lorcaserin HCL powder

Isilinganiselwa: SKU: 1431697-94-7. Isigaba:

I-AASraw inokukwazi ukuqala nokukwazi ukukhiqiza kusuka kugramu ukuya ku-mass of Lorcaserin HCL powder (1431697-94-7), ngaphansi komthethonqubo we-CGMP kanye nesistimu yokulawula ikhwalithi.

I-Lorcaserin (1431697-94-7) i-HCL powder kuthinta izimpawu zamakhemikhali ebuchosheni obulawula ukudla. I-Lorcaserin HCL powder isebenza ngokusiza ukuba uzizwe ugcwele ngokudla okuncane.I-corcaserin hydrochloride powder isetshenziselwa kanye nokudla nokuzivocavoca ukuphatha ukukhuluphala.Izinye izikhathi zisetshenziselwa ukuphatha ukukhuluphala okungase kuhlobene nesifo sikashukela, i-cholesterol ephakeme noma ukucindezelwa kwegazi eliphezulu .

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Product Incazelo

 

I-Lorcaserin (1431697-94-7) ividiyo

 

 


 

Ama-Lorcaserin (1431697-94-7) ama-Character eziyisisekelo ze-HCL

 

Igama: Lorcaserin hydrochloride powder
CAS: 1431697-94-7
Ifomula Yamamolekhula: C11H15Cl2N
Isisindo Yamamolekhula: 232.1525
I-Melt Point: 212 ° C
Isitoreji Sokugcina: -20 ℃
Umbala: powder emhlophe

 


 

Kuyini i-Lorcaserin

 

I-Lorcaserin (i-CAS 1431697-94-7), edayiswa ngaphansi kwegama lohlobo yi-BELVIQ, isithako esiyinhloko i-Lorcaserin HCL powder 846589-98-8. I-FDA ivume i-lorcaserin HCL kubantu abakhuluphele (nge-index mass mass, noma BMI, ye-30 noma ngaphezulu) noma abakhuluphele kakhulu (abane-BMI ye-27 noma ngaphezulu) futhi banesimo sempilo esihlobene nesisindo esisodwa okungenani njengohlobo lwe-2 yesifo sikashukela, umfutho wegazi ophakeme noma i-cholesterol ephakeme.

 

Yini uLorcaserin ayisebenzisayo

 

I-Lorcaserin HCL powder i-846589-98-8, iseklasini lemithi eyaziwa ngokuthi i-serotonin receptor agonists. I-Lorcaserin HCL isetshenziselwa ukudla kanye nokwakhiwa komzimba ukuphatha ukukhuluphala, ngokulahlekelwa kwamafutha. Ngezinye izikhathi kunikezwa ukuphatha ukukhuluphala okuhlobene ne-cholesterol ephezulu, ukucindezelwa kwegazi, noma isifo sikashukela se-Type2. Kodwa i-Lorcaserin hydrochloride (i-Lorcaserin HCL) ngeke iphathe noma yiziphi izimo zempilo ezingaphansi (njengesifo senhliziyo, isifo sikashukela, umfutho wegazi ophezulu).

 

Lorcaserin indlela yokwenza

 

I-Lorcaserin hydrochloride powder isebenza ngokulawula ukudla - ikakhulukazi ngokusungula ama-receptor ebuchosheni nge-serotonin, i-neurotransmitter edala imizwa yokuzondeka nokwaneliseka. Ukutholakala kokudla kulawulwa yisikhungo satiety, esivela ku-nucleus ye-hyperhalamus ye-ventromedial ne-hunger centre ekhona kamuva kwe-hypothalamus. Iziphakamiso ezihlukahlukene ezivela ezikhungweni eziphakeme kanye namapheshana amathumbu aguqukela ekuqhumeni i-nucleus, lapho kunezinhlobo ezimbili ze-neurons ezilawula ukudla okukhona. Okokuqala, iqembu lokuvuselela ukudla likhiqiza amaprotheni ahlobene ne-agouti ne-neuropeptide Y; futhi okwesibili, iqembu lokudla lokuvimbela ukudla eliqukethe i-cocaine ne-amphetamine lilawulwa ngokubhala (CART) ne-pro-opiomelanocortin (POMC) neurons. I-POMC iqukethe i-5-HT 2C receptors, lapho kusetshenzwa kukhishwa i-alpha-melanocyte-stimulating hormone (i-alfa-MSH) .Iziphetho ezingavimbelayo nezishukumisayo zenza amaphrojekthi amaphuzu avela phezulu kwi-hypothalamus.I-nucleus yezintambo iqukethe i-melanocyte 4 receptors (MC4R) evimbela ukondla Amanani ama-lorcaserin enza njenge-5-HT 2C agonist ekhethiwe kwi-POMC neurons, okuholela ekukhululeni i-alfa MSH. I-alfa e-MSH eqhubekayo isebenza nge-MC4R enqenqemeni yesibhakabhaka e-hypothalamus, eholela ekwehleni kwesifiso. Ezikhatsini ze-supratherapeutic, i-lorcaserin nayo isebenza ku-5-HT 2B kanye ne-5-HT 2A receptors.

 

Indlela yokusebenzisa i-Lorcaserin HCL powder (i-CAS 1431697-94-7)

 

I-Lorcaserin HCL powder iyi-powder emhlophe ephuma emhlophe enokuncibilika emanzini amakhulu kune-400 mg / mL. Ithebhulethi ngayinye ye-BELVIQ XR iqukethe i-20.8 mg ye-crystalline lorcaserin hydrochloride hemihydrate, elingana no-20.0 mg lorcaserin hydrochloride powder, kanye nezithako ezingasebenzi ezilandelayo: microcrystalline cellulose NF; i-mannitol USP; i-hypromellose 2208 USP; uhlobo lokusabalalisa lwe-ethylcellulose Uhlobo B NF; i-hypromellose 2910 USP; i-colloidal silicon dioxide NF; polyvinyl utshwala USP; i-polyethylene glycol NF; i-titanium dioxide USP; i-talc USP; I-FD & C ephuzi # 6 / ukushona kwelanga i-FCF; ichibi le-aluminium; i-iron oxide ephuzi i-NF; i-iron oxide ebomvu i-NF; kanye ne-magnesium stearate NF.

I-Lorcaserin HCL powder i-846589-98-8 ifika efomini yethebhulethi futhi ithathwa izikhathi ezingu-1-2 ngezikhathi, noma ngaphandle kokudla. I-Lorcaserin kumele isetshenziswe kanye nokudla okunciphile khalori kanye nohlelo lokuzivocavoca.

 

I-Lorcaserin Ukusebenzisana

 

-monoamine oxidase inhibitors njenge-isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Emsam, Eldepryl, Zelapar), i-rasagiline (Azilect)

-Serotonin reuptake inhibitors (SSRIs) njenge-escitalopram (Lexapro), i-sertraline (i-Zoloft), i-citalopram (iCelexa), i-paroxetine (i-Paxil), i-fluoxetine (i-Prozac, i-Sarafem), ne-fluvoxamine (i-Luvox)

-tricyclic antidepressants ezifana trimipramine (Surmontil), amitriptyline (Elavil), nortriptyline (Pamelor, Aventyl), protriptyline (Vivactil), ne-clomipramine (i-Anafranil)

 


 

Indlela yokuthenga i-Lorcaserin HCL powder (i-CAS 1431697-94-7) esuka ku-AASraw

 

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