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I-Lapatinib powder (i-231277-92-2)

Isilinganiselwa:
5.00 koku 5 ngokusekelwe ku 1 isilinganiso ikhasimende
SKU: 231277-92-2. Isigaba:

I-AASraw inokukwazi ukuhlanganisa nokukhiqiza amandla kusuka kugramu ukuya ku-mass mass ye-Lapatinib powder (231277-92-2), ngaphansi komthethonqubo we-CGMP kanye nesistimu yokulawula ikhwalithi.

Product Incazelo

Lapatinib powder isiqophi Ukugunda


I-Lapatinib powder Izinhlamvu eziyisisekelo

Igama: I-Lapatinib powder
CAS: 231277-92-2
Formula Yamamolekhula: C29H26ClFN4O4S
Isisindo somzimba: 581.05
I-Melt Point: I-136-140 ° C
Isitoreji Sokugcina: Isiqandisisi
Umbala: Mhlophe noma uphahla i-white Crystalline powder


I-Raw Lapatinib powder ku-Antineoplastic Agent cycle

Amagama

Igama elijwayelekile: I-Lapatinib powder (la PA tin ib)
Igama logama: Tykerb

Ukusetshenziswa kwe-Raw Lapatinib powder

I-Lapatinib powder iyimithi yokwelapha esetshenziswa ngomunye umuthi (capcitabine) ukuphatha abantu ngomdlavuza webele oye wanda kwezinye izindawo zomzimba okuyi-HER2 enhle (izicubu ezikhiqiza inqwaba yamaprotheni okuthiwa i-epidermal growth factor receptor-2) , futhi ngubani osevele enesinye imithi yomdlavuza webele.

I-Lapatinib powder nayo isetshenziselwa uhlobo lwezokwelapha okuthiwa i-letrozole yokwelashwa kwabesifazane be-postmenopausal abane-hormone receptor positive, umdlavuza webele we-HER2 omuhle wezinyosi lapho i-hormonal therapy iboniswa khona.

I-Lapatinib powder iyimithi yokwelapha esetshenziswa ekwelapheni umdlavuza webele. Isetshenziselwa ukuhlanganiswa neminye imithi yokwelapha uhlobo oluthile lomdlavuza webele olusakazekele kwezinye izingxenye zomzimba futhi olungaphenduli kwezinye izifo zomdlavuza.

I-Lapatinib powder ingeqembu lezidakamizwa okuthiwa i-kinase inhibitors elisebenza ngokuvimbela isenzo seprotheyini ethile esho ukuthi amaseli omdlavuza aphindwe.

Le mithi ivela efomini yethebhulethi futhi ithathwa kanye ngosuku ngalunye esiswini esingenalutho.

Imiphumela emibi evamile ye-Lapatinib powder ihlanganisa izandla ezibomvu, ezibuhlungu nezinyawo, isifo sohudo, ukuqhuma, nokucabangela.

Iyiphi isilinganiso seLatatinib powder

Ukusebenzisa i-Adult Dose for Cancer Breast

-I-CANCER (ihlanganiswa ne-capecitabine) ye-HER2-POSITIVE (ehlangene ne-capecitabine): 1250 mg ngomlomo kanye ngosuku ngezinsuku ze-1 kuya ku-21 ngokuqhubekayo ngokuphinda imijikelezo yezinsuku ze-21 kuze kuqhubeke ukuguquka kwesifo noma ubuthi obungavumelekile.

I-HORMONE RECEPTOR-POSITIVE, I-HER2-POSITIVE METASTATIC BREAST CANCER (ehambisana ne-letrozole): 1500 mg ngomlomo kanye ngosuku.

Amazwana:
-Ukuthola ulwazi lomkhiqizo womkhiqizo we-capecitabine nezincomo ze-letrozole dosing.
-Iziguli ze-metastatic ze-metastatic zeHER2-positive kufanele zibe nokuqhubeka kwezifo ku-trastuzumab ngaphambi kokuqala ukwelashwa nalesi sidakamizwa ngokuhambisana ne-capecitabine.

Ukusebenzisa:
-Ukuhlanganiswa ne-capecitabine yokwelashwa kweziguli ezinomdlavuza ophuthumayo noma we-metastatic wezinambuzane ezinama-tumors overexpress HER2 nalabo abaye bathola ukwelapha kwangaphambi kokufaka i-anthracycline, itekane, ne-trastuzumab.
-Ukuhlanganiswa ne-letrozole yokwelashwa kwabesifazane be-postmenopausal abane-hormone-positive positive metastatic umdlavuza webele we-hormone receptor-positive okuyinto ephazamise kakhulu i-HER2 receptor okuboniswa ngayo ukwelashwa kwe-hormonal.

Ukulungiswa Kwama-Renal Dose
Idatha ayitholakali mayelana nokulungiswa kwesilinganiso; Kodwa-ke, i-pharmacokinetics yalesi sidakamizwa cishe ayithintekile ngenxa yokuthi okungaphansi kwe-2% yesilinganiso esilawulwayo isuswa yizinso.

Ukulungiswa kwesibindi Ukulungiswa
UMSEBENZI WOKUPHILA UKUPHILA UKUPHATHISA IMPILO YEZEMPILO (I-CHILD-PUGH A / B): Idatha ayitholakali.

UKUPHUMA OKUPHILA KWE-HEPATIC IMPAIRMENT (CHILD-PUGH C): Nciphisa umthamo:
-HER2-Positive Canast Metastatic Breast Cancer (ehambisana ne capecitabine): 750 mg / ngosuku.
-Hormone Receptor-Positive, HER2-Positive Metastatic Breast Cancer (kuhlanganiswe ne letrozole): 1000 mg / ngosuku

KUNYE NE-HEPATOTOXICITY OCCURS NGOKUKHAMBA: Ukuyeka unomphela ukwelashwa.

Amazwana: Izincomo zokulungiswa kwezintambo zisekelwe kwizifundo ze-pharmacokinetic; ayikho idatha yomtholampilo etholakalayo.

Ukulungiswa kweDose
UMTHETHO WOKUSETSHENZISWA NABASEBENZI BE-CYP450 3A4 NOMA / NOMA KANYE NABASEBENZI BE-CYP450 3A4: Gwema ukusebenzisa okuhambisanayo uma kunokwenzeka. Izincomo zokulungiswa kwezintambo zisekelwe kwizifundo ze-pharmacokinetic; ayikho idatha yomtholampilo etholakalayo.
UMTHETHO WOKUSETSHENZISWA NESIKHATHI SESIKHATHI SIKHXXUMUMA 450A3 INHIBITOR: Nciphisa umthamo ku-4 mg / ngosuku; vumela isikhathi se-shuttle cishe seviki le-500 ngaphambi kokulungiswa okuqhubekayo kwalesi sidakamizwa kumthamo ophakanyisiwe owenzelwe uma i-inhibitor ingaqediwe.
UMTHETHO WOKUSETSHENZISWA NESIKHATHI SE-CYP450 3A4 INDUCER: Umthamo we-titrate okhuphuka kancane ngokusekelwe ekubekezekeni; ukunciphisa umthamo emuva kwenzalo evamile yokunconywa uma i-inducer ivaliwe.
-HER2-Positive Cancer Metastatic Breast Cancer (kuhlanganise ne capecitabine): Ukwandisa umthamo kuze kube yi-4500 mg / ngosuku.
-Hormone Receptor-Positive, HER2-Positive Metastatic Breast Cancer (kuhlanganiswe ne letrozole): Ukwandisa umthamo kuze kube 5500 mg / ngosuku.

IGREYIDI 2 noma UKUQALA OKUHLELA KWEZINDLELA ZOKWENZA IZINDLELA ZOKUPHILA (LVEF) NOMA UKUPHILA OKUHLELA UKUQALA KWEMISEBENZI YOKUSEBENZA KWAMAZIKO: Ukuyeka ukwelashwa; ingase iqalise kabusha ngesilinganiso esinciphile ngemuva kokungenani kwamaviki angu-2 uma i-LVEF ibuyele evamile futhi isiguli singenakwenzeka.
Amanani okunciphisa:
-HER2-Positive Canast Metastatic Breast Cancer (ehlangene ne-capecitabine): 1000 mg / ngosuku
-Hormone Receptor-Positive, HER2-Positive Metastatic Breast Cancer (kuhlanganiswe ne letrozole): 1250 mg / ngosuku

IBANGA 3 NOMA IBHAYIBHELI 1 noma i-2 DIARRHEA EZIPHUMA EZIPHUMELEKAYO (ukulinganisela ukuya ekomelweni eliphansi kwesisu, i-Grade 2 noma i-nausea enkulu noma ukuhlanza, ukunciphisa isimo sokusebenza, umkhuhlane, isisu, i-neutropenia, ukuphuma kwe-frank, noma ukuphelelwa amanzi): Ungase uphinde uvuselele umthamo ophansi lapho uhudo ixazulula ku-Grade 1 noma ngaphansi.
Amanani okunciphisa:
-I-patient ye-HER2-positive ye-Breast Metastatic Breast Cancer (inhlanganisela ne-capecitabine): 1000 mg / ngosuku
-Hormone Receptor-Positive, HER2-Positive Metastatic Breast Cancer Iziguli: 1250mg / ngosuku
IBANGA LE-4 DIARRHEA: Unqume unomphela ukwelashwa.

EZINYE IZIKHAYA, IBANGA 2 noma ELIKHULU: Kungabheka ukuyeka noma ukuphazanyiswa kokulandelwa; ingase iqalise kabusha ngesilinganiso esivamile sokunconywa lapho ubuthi obuphuthumayo bubonakala kuGreyidi 1 noma ngaphansi.
Uma i-TOXICITY RECURS: Nciphisa umthamo:
-HER2-Positive Canast Metastatic Breast Cancer (ehlangene ne-capecitabine): 1000 mg / ngosuku
-Hormone Receptor-Positive, HER2-Positive Metastatic Breast Cancer Iziguli: 1250mg / ngosuku

Yeka indlela i-Lapatinib powder engasebenzi ngayo esebenza ngayo

I-Lapatinib powder isetshenziselwa i-capecitabine (Xeloda) yokwelapha uhlobo oluthile lomdlavuza wesifuba ophuthumayo kubantu abaye baphathwa ngezinye izidakamizwa zamakhemikhali. I-Lapatinib powder iseklasini lemithi ebizwa ngokuthi i-kinase inhibitors. Isebenza ngokuvimbela isenzo seprotheyini engavamile ekhombisa amangqamuzana omdlavuza ukuba aphindwe. Lokhu kusiza ukuma noma ukunciphisa ukusakazeka kwamangqamuzana omdlavuza.

Isexwayiso

Tshela bonke abahlinzeki bakho bezempilo ukuthi uthatha i-Lapatinib powder. Lokhu kuhlanganisa odokotela bakho, abahlengikazi, abemithi kanye namazinyo.
Uma uphethwe yisisu, ukuphonsa, izihlalo ezivulekile (uhudo), noma abalambile, khuluma nodokotela wakho. Kungase kube khona izindlela zokunciphisa le mibi emibi.
Izitofu ezilahlayo (isifo sohudo) zenzeke nePapatinib powder. Ngezinye izikhathi, isifo sohudo sibi kakhulu futhi ukufa sekuye kwenzeka. Khuluma nodokotela wakho.
Uma unezihlalo ezivulekile (uhudo), khuluma nodokotela wakho. Ungazami ukwelapha isifo sohudo ngaphandle kokuhlola kuqala udokotela wakho.
Yenza umsebenzi wegazi uhlolwe njengoba utshele udokotela. Khuluma nodokotela.
Kuzodingeka ube nokuhlolwa komsebenzi wenhliziyo ngenkathi uthatha i-Lapatinib powder. Khuluma nodokotela.
Gwema i-grapefruit kanye nejusi lamagilebhisi.
Uma uthatha digoxin, khuluma nodokotela wakho. Kungase kudingeke ukuthi umsebenzi wakho wegazi uhlolwe ngokuseduze uma uwathatha nge-Lapatinib powder.
Le mithi ingalimaza ingane engakazalwa uma uyithatha ngenkathi ukhulelwe.
Sebenzisa ukubeletha ongayethemba ukuvimbela ukukhulelwa ngenkathi uthatha i-Lapatinib powder.
Uma ukhulelwe noma ukhulelwa ngenkathi uthatha i-Lapatinib powder, shayela udokotela wakho ilungelo.

I-Lapatinib Raw Powder

I-oda elincane le-10grams.
Ucwaningo ngobuningi obujwayelekile (ngaphakathi kwe-1kg) lungathunyelwa kumahora angu-12 ngemuva kokukhokha.
Ukuhlelwa okukhulu kungathunyelwa ezinsukwini zokusebenza ezingu-3 ngemuva kokukhokha.

I-Lapatinib powder Marketing

Ukuze unikezwe esikhathini esizayo.

Ingabe i-Lapatinib powder eluhlaza kunayo yonke imiphumela emibi

Kanye nemiphumela yayo edingekayo, i-Lapatinib powder ingabangela ezinye izinto ezingadingeki. Nakuba zonke lezi zemibala zingase zenzeke, uma zenzeke zingadinga usizo lwezokwelapha.

Hlola nodokotela wakho ngokushesha uma kukhona okunye okulandelayo okumele kwenzeke ngesikhathi uthatha i-Lapatinib powder:

Okungajwayelekile
Ukuphefumula okunzima noma okusebenzayo
ukuphelelwa amandla
ukushaya kwenhliziyo okusheshayo noma okungavamile
isifo sohudo oluqinile
ukuqina kwesifuba
ukukhathala okungavamile noma ubuthakathaka
ezingavamile

Ubuhlungu besisu noma isisu noma isisa
izitshalo ezinobumba
umchamo omnyama
ukunciphisa ukudla
imfiva
bekhanda
ukushaywa noma ukukhwabanisa isikhumba
ukulahlekelwa ukudla
isicanucanu nokuhlanza
ukuvuvukala kwezinyawo noma imilenze ephansi
amehlo aphuzi noma isikhumba
Isimo esingaziwa
Ukuqhaqhazela, ukukhipha, ukukhipha isikhumba
ubuhlungu besifuba
izikhukhula
ukhwehlela
uhudo
ubunzima ngokugwinya
isiyezi
umuzwa ovamile wokungahambi kahle noma ukugula
imihlathi
ubuhlungu obuhlangene noma bomzimba
ukukhukhumeza noma ukuvuvukala kwamajwabu amehlo noma eduze kwamehlo, ubuso, izindebe noma ulimi
izilonda zesikhumba esibomvu, ngokuvamile ziyisikhungo esinomsundu
amehlo abomvu, acasulayo
Umphimbo obuhlungu
izilonda, izilonda noma amabala amhlophe emlonyeni noma ezindebeni
ukuqina kwemfihlo yokwehla
Ezinye imiphumela emibi ye-Lapatinib powder kungenzeka ukuthi ngokuvamile ayidingi ukunakekelwa kwezokwelapha. Le miphumela emibi ingase ihambe ngesikhathi ukwelashwa njengoba umzimba wakho ulungisa umuthi. Futhi, uchwepheshe wakho wokunakekelwa kwezempilo angakwazi ukukutshela ngezindlela zokuvimbela noma ukunciphisa ezinye zalezi zemibala. Hlola nge-professional care professional yakho uma ngabe kukhona eminye imiphumela emibi eqhubekayo noma ephazamisayo noma uma unemibuzo mayelana nabo:

Okuvamile
I-Acid noma isisu esisimuncu
ukuhlungu obusemhlane
ukubamba
izindebe eziphahliwe
isifo sohudo (omnene)
isikhumba esomile
ukushaya kwenhliziyo
indigestion
ubuhlungu ezandleni noma emilenzeni
ubomvu, ukuvuvukala, noma isikhumba esibuhlungu
ukukala kwesikhumba ezandleni nasezinyaweni
izilonda, izilonda noma izindawo ezimhlophe ezindebe, ulimi, noma ngaphakathi emlonyeni
ukungahambi kahle kwesisu, ukucasuka, noma ubuhlungu
ukuvuvukala noma ukuvuvukala komlomo
ukubetha kwezandla nezinyawo
inkathazo yokulala


Indlela yokuthenga i-Lapatinib powder kusuka ku-AASraw

1.Ukuxhumana nathi nge-imeyili yethu uhlelo lokuphenya, noma isibhakabhaka se-inthanethiummeleli wenkonzo yamakhasimende (CSR).
I-2.Ukusihlinzekela ngobuningi bakho kanye nekheli lakho elibuziwe.
I-3.I-CSR yethu izokunikeza ikhothethini, isikhathi sokukhokha, inombolo yokulandelela, izindlela zokulethwa kanye nosuku lokufika olulinganisiwe (i-ETA).
I-4.Inkokhelo eyenziwe futhi izimpahla zizothunyelwa kumahora we-12 (Ukuhleleka ngaphakathi kwe-10kg).
Ama-5.Goods athola futhi anikeze imibono.


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COA

I-COA 231277-92-2 I-Lapatinib powder AASRAW

I-HNMR

Singama-Lapatinib powder supplie, i-Lapatinib powder ukudayiswa, i-Raw Lapatinib powder (231277-92-2) hplc =98% | Yenza ama-Reagents we-R & D

Ungadliwa

I-Lapatinib Raw Powder Recipes:

Ukuze uphenye ikhasimende lethu elimelelekile (CSR) ngemininingwane, ngokubhekisela kwakho.

Okubhekiselweyo nokuhlungwa komkhiqizo

U-Tykerb (231277-92-2) -Umbulali webele