Izici Eziyisisekelo

Igama Product	I-Nicotinamide riboside chloride
CAS Inombolo	23111-00-4
Formula Yamamolekhula	C11H15ClN2O5
Isisindo sesisindo	290.7
omqondofana	23111-00-4 I-Nicotinamide riboside chloride I-Nicotinamide riboside (i-chloride) 3-Carbamoyl-1-((2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride I-nicotinamide ribose chloride
ukubukeka	powder emhlophe
Isitoreji nokuphatha	0 - 4 C isikhathi esifushane (izinsuku kuya emavikini), noma -20 C isikhathi eside (izinyanga).

 

Incazelo yeNicotinamide riboside chloride

I-Nicotinamide Riboside Chloride (NIAGEN) yifomu kasawoti le-chloride le-nicotinamide riboside (NR) .NR ifomu elisha i-pyridine-nucleoside kavithamini B3 elisebenza njengesandulela se-nicotinamide adenine dinucleotide (NAD) noma i-NAD +. (GRAS) e-United States yokusetshenziselwa imikhiqizo yokudla. I-Nicotinamide riboside chloride ifomu le-crystal leNicotinamide riboside (NR) chloride. INicotinamide riboside chloride inyusa amazinga e-NAD [+] futhi isebenze i-SIRT1 ne-SIRT3, ifinyelela ekugcineni kwe-metabolism ye-oxidative ethuthukisiwe nokuvikelwa kokungajwayelekile kokudla okunamafutha okuphezulu. I-Nicotinamide riboside chloride powder isetshenziselwa izithako zokudla.

 

INicotinamide riboside chloride Mechanism of Action

INicotinamide Riboside Chloride (NIAGEN) yifomu kasawoti le-chloride le-nicotinamide riboside (NR). I-NR ifomu le-pyridine-nucleoside likavithamini B3 elisebenza njengesandulela se-nicotinamide adenine dinucleotide noma i-NAD +. I-NR ivimba ukonakala kwezimpande zomgogodla ezihlinzwe ngokuhlinzwa ezivikelwe futhi zivikela ekulahlekelweni kokuzwa okubangelwa umsindo kumagundane aphilayo. I-Nicotinamide riboside powder ivimbela imisipha, i-neural ne-melanocyte stem cell senescence. Ukwanda kokuvuselelwa kwemisipha kumagundane kuye kwabonwa ngemuva kokwelashwa nge-nicotinamide riboside, okuholela ekucabangeni ukuthi kungathuthukisa ukuvuselelwa kwezitho ezifana nesibindi, izinso nenhliziyo. INicotinamide riboside ibuye yehlise ushukela wegazi kanye nesibindi esinamafutha kuma-prediabetic bese uthayipha amamodeli wesifo sikashukela we-2 ngenkathi ivimbela ukuthuthukiswa kwe-peripheral neuropathy yesifo sikashukela. Qaphela: INicotinamide Riboside chloride ingxube ye-α / β.

 

Isicelo seNicotinamide riboside chloride

INicotinamide riboside chloride powder ibhaliswe nenombolo ye-CAS 23111‐00‐4 kanye nenombolo ye-EC 807‐820‐5. Igama layo le-IUPAC lingu-1 - [(2R, 3R, 4S, 5R) ‐3,4 ‐ dihydroxy ‐ 5‐ (hydroxymethyl) oxolan ‐ 2 ‐ yl] pyridin ‐ 1 ‐ ium ‐ 3 ‐ carboxamide; i-chloride. Ifomula yamangqamuzana e-nicotinamide riboside chloride yi-C11H15N2O5Cl, nesisindo sayo samangqamuzana esingu-290.7 g / mol. I-Nicotinamide Riboside Chloride (NIAGEN) yifomu kasawoti le-chloride le-nicotinamide riboside (NR) .NR ifomu elisha le-pyridine-nucleoside likavithamini B3 elisebenza njengesandulela se-nicotinamide adenine dinucleotide (NAD) noma i-NAD +. Umzimba udinga i-NAD + ukuze usebenze ngokujwayelekile. Amazinga aphansi we-NAD + angadala izinkinga zezokwelapha. Ukuthatha i-nicotinamide riboside kungasiza ukukhuphula la mazinga aphansi e-NAD +.

 

Izinzuzo I-Nicotinamide riboside chloride

I-Nicotinamide riboside Chloride, eyandulela ngomlomo ye-NAD +, inyusa amazinga we-NAD + futhi isebenze i-SIRT1 ne-SIRT3. I-Nicotinamide riboside I-chloride powder ingumthombo wevithamini B3 (niacin) futhi ukusebenzisa i-Nicotinamide riboside Chloride powder kungathuthukisa imetabolism ye-oxidative, ukuvikelwa ekuphambeni kwemithelela yokudla okunamafutha. INicotinamide riboside Chloride inciphisa ukuwohloka kokuqonda kwimodeli yegundane eguquguqukayo yesifo i-Alzheimer's.

 

Izikhombo

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[2] UBogan KL, uBrenner C. Nicotinic acid, i-nicotinamide, ne-nicotinamide riboside: ukuhlolwa kwamangqamuzana we-NAD + amavithamini angaphambi kokudla komuntu. U-Annu Rev Nutrr. 2008; 28: 115-30. i-doi: 10.1146 / annurev.nutr.28.061807.155443. Buyekeza. I-PMID ekhishwe: 18429699.

[3] UGhanta S, Grossmann RE, Brenner C. Mitochondrial protein acetylation as a cell-intrinsic, evolutionary driver of fat storage: chemical and metabolic logic of acetyl-lysine modifications. Crit Rev Biochem Mol Biol. 2013 uNov-Dec; 48 (6): 561-74. i-doi: 10.3109 / 10409238.2013.838204. Buyekeza. I-PMID ekhishwe: 24050258; I-PubMed Central PMCID: PMC4113336.

[4] I-Yang Y, i-Sauve AA. I-NAD (+) metabolism: Bioenergetics, signaling and manipulation for therapy. I-Biochim Biophys Acta. 2016 Dec; 1864 (12): 1787-1800. i-doi: 10.1016 / j.bbapap.2016.06.014. Buyekeza. I-PMID ekhishwe: 27374990.

[5] I-Sauve AA. I-NAD + ne-vitamin B3: kusuka ekusetshenzisweni komzimba kuya ekwelashweni. UJ Pharmacol Exp Ther. 2008 Mar; 324 (3): 883-93. i-doi: 10.1124 / jpet.107.120758. Buyekeza. I-PMID ekhishwe: 18165311.

[6] UKato M, uLin SJ. Ukulawulwa kwe-NAD + metabolism, ukusayina kanye nokuhlukaniswa kwamakhemikhali ku-yeast Saccharomyces cerevisiae. Ukulungiswa kwe-DNA (Amst). 2014 Novemba; 23: 49-58. i-doi: 10.1016 / j.dnarep.2014.07.009. Buyekeza. I-PMID ekhishwe: 25096760; I-PubMed Central PMCID: PMC4254062.

[7] UCantó C, et al. I-NAD (+) eyandulela i-nicotinamide riboside ithuthukisa imetabolism ye-oxidative iphinde ivikele nokukhuluphala kokudla okunamafutha aphezulu. Iseli Metab. 2012 Juni 6; 15 (6): 838-47.

[8] IBing Gong, et al. INicotinamide Riboside Ibuyisela Ukuqashelwa Ngokusebenzisa Ukwehliswa Kwe-Reactor-iv Coactivator esebenza nge-Proliferator 1α elawulwe β-Secretase 1 Ukucekelwa phansi kanye ne-Mitochondrial Gene Expression kuma-Alzheimer's Mouse Models. Ukuguga kwe-Neurobiol. 2013 Juni; 34 (6): 1581-8.

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