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I-Trilostane Powder (13647-35-3)

Isilinganiselwa: SKU: 13647-35-3. Isigaba:

I-AASraw ine-synthesis nekhono lokukhiqiza kusuka kugramu iye ku-oda le-Trilostane Powder (13647-35-3), ngaphansi komthetho we-CGMP kanye nohlelo lokulawula ikhwalithi olandelwayo.

Product Incazelo

I-Trilostane Powder (13647-35-3) ividiyo


I-Trilostane Powder (13647-35-3) Sukukhishwa:

Isakhiwo samakhemikhali: Igama Product: I-Trilostane
Cas Cha: 13647-35-3
Formula Yamamolekhula: C20H27NO3
isisindo Yamamolekhula: 329.43
Standard: Ngaphakathi
Isitoreji: Emile, emnyama futhi e-0 - 4 C okwesikhashana (izinsuku kuya emavikini) noma -20 C isikhathi eside (izinyanga kuya eminyakeni).
Imibhalo (COA & HPLC njll): Iyatholakala

I-Trilostane Powder (13647-35-3) Dukubhalwa:

I-Trilostane powder iyi-inhibitor ye-3β-hydroxysteroid dehydrogenase esetshenziswa ekwelapheni i-Cushing's syndrome kanye ne-hyperaldosteronism eyinhloko. Lezi zinkinga zombili lapho kukhiqizwa khona inani eleqile lama-corticosteroid mahmesse emzimbeni. Ama-corticosteroids abalulekile ukuze umzimba usebenzise ama-carbohydrate, amafutha kanye namaprotheni kanye nokuphendula okujwayelekile ekuxinekeni. Ziyadingeka futhi ekuphatheni umthetho kasawoti nokulingana kwamanzi emzimbeni. I-Trilostane powder isiza ukuvikela ukukhiqizwa kwe-corticosteroids, ukulawula izimpawu ezihambisana nalokhu kuphazamiseka.

I-Trilostane powder nayo ingaba wusizo ekwelapheni umdlavuza webele oye wabuyela kwabesifazane abaye badlula esikhathini sokuya esikhathini.

Kusanda kuvunywa ngonyaka ka-2008 ukwelashwa kwezifo zeCushing (hyperandrenocorticism) ezinjeni. Futhi yisidakamizwa sokuqala esivunyiwe ukwelapha i-Cushing's esezinhlwini nasezinhlafunweni. Lesi sidakamizwa esikhonjelwe sisebenza ngokumisa ukukhiqizwa kwe-cortisol emithanjeni ye-adrenal.

Izikhombo:

  • 1: Midence JN, Drobatz KJ, Hess RS. Ukuqondiswa kweCortisol kuzinja ezilawulwa kahle nge-Hyperadrenocorticism Iphathwe neTrostostane. J Vet Intern Med. I-2015 Nov; 29 (6): 1529-33. doi: 10.1111 / jvim.13615. Epub 2015 Sep 16. I-PubMed PMID: 26374943.
  • 2: UFracassi F, uCorrr S S, uFloriano D, uBoari A, u-Aste G, uPietra M, uBergamini PF, uDondi F. Izici ezinengqondo zokusinda ezinjeni ezinama-hypercortisolism asesimweni esincanyana aphethwe nge-trilostane. I-Vet Rec. 2015 Jan 10; 176 (2): 49. doi: 10.1136 / vr.102546. Epub 2014 Aug 28. I-PubMed PMID: 25170036.
  • I-3: I-Bonadio CM, i-Feldman EC, i-Cohen TA, i-Kass PH. Ukuqhathaniswa kwemiphumela yokuhlolwa kwe-hormone ye-adrenocorticotropic yaqala 2 kanye namahora we-4 ngemuva kokuphathwa kwe-trilostane ezinjeni ezinama-hyperadrenocorticism ngokwemvelo. J Vet Intern Med. 2014 Jul-Aug; 28 (4): 1239-43. doi: 10.1111 / jvim.12357. Epub 2014 Meyi 26. I-PubMed PMID: 24863172.

UKUHLELWA KANYE Nesitatimende:

Le Material ithengiswa Ukusetshenziswa Kocwaningo Kuphela. Imibandela Yokuthengisa Faka isicelo. Hhayi Ukusetshenziswa Komuntu, noma Ezokwelapha, Izilwane, noma Ukusetshenziswa Kwasekhaya.


COA

I-HNMR

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