Umhlahlandlela Ophelele Wokuthenga We-SARM SR9009 Ukwakha Umzimba
I-AASraw ikhiqiza izimpushana ze-NMN ne-NRC ngobuningi!

 

Umhlahlandlela Ophelele Wokuthenga 2019 We-SR9009 Wokwakha Imisipha Engaphezulu

 

I-1.Yini SR9009?

SR9009 noma i-stenabolic iyisengezo se-CAS 1379686-29-9 esilingisa imiphumela yokuzivocavoca kwe-cardio. Umuthi awuzukusiza kuphela ukunciphisa amanye amafutha akho emzimbeni, kodwa futhi kuzothuthukisa amandla akho ngenkathi kukhulisa ukukhuthazela.

I-SR9009 iyi-synthetic synthetic, eyavela ngokunqunyelwa kukaSolwazi Thomas Burris. Ihlobene kakhulu ne I-SARMS (Ukukhetha i-Androgen Receptor Modulators), kepha kuyangidabukisa iprotheni ye-Rev-Erbcy etholakala emthanjeni wamathambo, izicubu ze-adipose, ubuchopho kanye nesibindi.

UProfesa Burris waqhamuka naye SR9009 (I-1379686-29-9), ihlose ukutadisha nokuqonda isigqi se-circadian.

 

I-2.Isebenza kanjani i-SR9009?

Uyawazi lowo muzwa owuthola ngemuva kokugijima i-2km kusitebhisi noma uphakamise amanye amarobhothi? Well, SR9009 isisindo somzimba kuzokwenza uzizwe ngendlela efanayo. I-supplement inendima ekuguqulweni kwe-circadian, umthethonqubo we-lipid, kanye nokulawula kwamazinga kashukela.

I-SR9009 SARM ibamba iqhaza elibalulekile ekuvuseleleni i-Rev-Erb. Le protein iphazamisa amandla omzimba wokushisa amafutha amaningi, ushukela, ne-cholesterol embi. Ngakho-ke, inyusa inqubo yokwehlisa isisindo ngenkathi ithuthukisa ukukhuthazela. Noma ngabe ubulolonga umzimba, uzozizwa unamandla futhi ungakhathali kangako ukuze ukwazi ukuzivocavoca umzimba ngokwengeziwe.

I-stenabolic igaya amafutha, i-lipids, noshukela. Lapho ukusetshenziswa kukaphethiloli komzimba kukhulu, khona-ke ngokungangabazeki uzothola ukusebenza okuphezulu. Esifundweni sangaphambi kokusebenzisa imodeli ye-murine, amagundane abengaphansi kwe- I-SR9009 powder (I-1379686-30-2) umthamo ungaqhubeka ngokushesha ngokushesha kunangaphambili. Le ngxenye yobufakazi ingaba yisizathu esenza ukuthi i-stenabolic ifakwe kuhlu phakathi kwezidakamizwa ezingavunyelwe kwezemidlalo.

Uma ungeyena umuntu we-maniac wokuzivocavoca, lezi zindaba yilokho izindlebe zakho ezifisa ukukuzwa. I-stenabolic ibuye iphindwe kabili isilinganiso sakho semethabhothi ngenkathi uphumule. Ngemuva kokudla, umzimba wakho ngokujwayelekile ukuguqula ukudla kube ngamafutha. Kodwa-ke, isithasiselo sokulahlekelwa kwesisindo se-SR9009 sizokhulisa ngokushesha imetabolism yokuthi uzoqala ukushisa la mafutha khona manjalo.

Ucwaningo lwakamuva lukhombisa ukuthi i-stenabolic yi-ejenti elwa nomdlavuza. Umphikisi womdlavuza we-SR9009 uthinta abashayeli be-oncogenic, kufaka phakathi i-PIK3CA, HRAS, ne-BRAF. Kumaseli ayingozi, umkhiqizo ufaka i-apoptosis futhi ukhubazeke ukukhula kwesimila ngaphandle kokubanga imiphumela emibi.

 

Umhlahlandlela Ophelele Wokuthenga 2019 We-SR9009 Wokwakha Imisipha Engaphezulu

 

I-3.Indlela Yokusebenzisa i-SR9009

Ngaphandle kokulebula ukusetshenziswa kwelebula ye-SR9009 athole inzuzo yemisipha izidakamizwa, isengezo sinamanani abalulekile emithi. Ochwepheshe bemitholampilo bayincoma kakhulu ukuthi iziguli ezinesifo sikashukela nalabo bantu abanokuhlaselwa yisifo sohlangothi bahlukunyeziwe.

Uma uhlela ukuphatha i-SR9009 powder (1379686-30-2) yokulawula ukugula kwakho, qiniseka ukuthi ukhuluma nodokotela wakho ngaphambi kwesikhathi. Umuthi uphephile, kepha udokotela wakho kumele akweluleke ngemithi ekhona ngenkathi ubheka noma yiziphi izimpawu ezingezinhle.

Ngokusetshenziswa kwelebuli engekho, umthamo ojwayelekile we-SR9009 umayelana ne-30mg / ngosuku. Umthamo uhlukaniswe kathathu.

Uma ngemuva kokukhuthazela, kufanele uthathe u-supplement ngaphambi nje kokushaya ejimini. Isizathu ukuthi i-SR9009 ine-half-life; ngakho-ke, imiphumela ivela ngokukhanya. Okufanelekile, ukuphathe ngaphambi kokudla ukuze ukwazi ukugcina umzimba usebenza kahle usuku lonke.

 

I-4.Izimpawu zeSR9009, Ngabe Ulindeleni?

  • Nyusa Ukulahlekelwa Isisindo

I-SR9009 SARM ithuthukisa izinqubo ze-metabolic. Lapho ukungenisa sekwenzekile, i-stenabolic ibizohlela umzimba ukuthi ushise ama-calories amaningi kunokuwuguqula ube ngamafutha. Isengezo asilinganisi nje kuphela izakhi zofuzo ezigcina amafutha, kodwa futhi sinciphisa ukukhiqizwa kwamaseli amasha amafutha esibindini.

Uma umgomo wakho ukunciphisa umzimba, qiniseka ukufaka phakathi imisebenzi yokomzimba ejwayelekile yakho. Ukusebenza ngaphandle, ukudla, nokuthatha i-SR9009 pre Workout supplement kusheshisa ukushiswa kwamafutha ngokweqile. Ucwaningo lukhombisa ukuthi ukusebenzisa i-stenabolic kwehlisa amanoni acid ne-plasma triglycerides okuhlushwa yi-23% ne-12%, ngokulandelana.

Ezimweni ezikhuluphele lapho ukusebenza noma ukudla kungabeyona inketho, odokotela cishe bazonquma lokhu okungeziwe.

Ihlela ukubuyekezwa kwamakhasimende, umsebenzisi oyedwa uqinisekise ukuthi i-SR9009 powder (1379686-30-2) umsize ukuthi alahle amakhilogremu we-17 ezinyangeni ezintathu.

  • Ukukhula Kwemisipha

Lesi sithasiselo asigcini ngokwandisa ubukhulu bemisipha kepha sithuthukisa namandla nokusebenza kwaso. Umuzwa owuthola ngemuva kokufaka isilinganiso se-SR9009 ulingana nalowo wokuphakamisa izinsimbi.

Umuthi uvusa ukukhiqizwa okukhulu kwe-mitochondria ngaphakathi kwamangqamuzana emisipha, yingakho kukhulisa imetabolism. Lawa ma-organelles anesibopho sokukhiqiza amandla ezicutshini zemisipha. Ngaphandle kwalokho kuzoba nokwanda kokusetshenziswa kwama-glucose kanye nokusetshenziswa kwamafutha acid ngaphakathi kwezicubu.

Ngokomtholampilo, i-SR9009 izuzisa asebekhulile abahlushwa ukonakala kwemisipha noma i-sarcopenia.

  • Ukwandisa Ukukhuthazela

Iningi labavocavoci bomzimba ngeke liphuthelwe ukufaka imisipha ye-SR9009 ohlelweni lwabo lokwakha umzimba. Uzophakamisa izinsimbi, usebenzise umshini wokunyathelisa, noma wenze noma ikuphi ukuzivocavoca umzimba ngaphandle kokuzizwa ukhathele noma unenhloko encane.

Isengezo ngokungangabazeki sizothatha ukusebenza kwakho njenge-notch ephakeme kunangaphambili. Uma ubucabanga ukuthi lezi zinzuzo ze-SR9009 zingumkhonyovu, kufanele ubuze ukuthi kungani i-anti-doping agency izokuvimbela ngokuqinile ukusetshenziswa kwayo kwezemidlalo yokuncintisana.

Njengoba uThomas Burris, umsunguli we-Stenabolic, esho, lesi sidakamizwa sikuguqula ube ngumsubathi ongumakadebona esikhathini esithile. Ngeke uphelelwe amandla noma amandla noma ngabe wenza izivivinyo ezinkulu.

  • Khulisa ukuvuka

Uma uhlala ulele phakathi nosuku, i-stenabolic ingaba yikhambi lakho elilandelayo. Esifundweni sokuqala, isengezo sabonakala siguqula indlela yokulala yamamodeli we-murine. Ososayensi baphawula ukuthi la magundane ayephapheme kakhulu phakathi nosuku, futhi akukho noyedwa kubo owakwazi ukulala ubuthongo obukhulu. Ngakho-ke, uma ufuna ukungena kwisigqi sakho se-circadian ukuze ushintshe iphethini yakho yokulala, i-SR9009 izokwenza ngentokozo ukukwenza.

Ngenxa yesigamu sempilo ye-SR9009, umphumela wokuvuka uzoba wesikhashana. Ngakho-ke, ngeke ube ne-insomniac usuku lonke.

  • Ukulimala Kwethishu (Fibrosis)

Ucwaningo luqinisekisa ukuthi amagundane anesibindi i-fibrosis alulama ngokuphelele ngemuva kokuthatha i-SR9009 amasonto amabili.

  • Kuvikela Izifo Zenhliziyo

Esimweni lapho inhliziyo ikhula ngokungajwayelekile, i-SR9009 powder (1379686-30-2) isebenza ukuguqula umehluko ngokunciphisa usayizi wesitho nesisindo. Ngenkathi amanye amagundane anemithambo elukhuni ephathwa nge-stenabolic, abacwaningi baphawula ukwehliswa kosayizi bezilonda zemithambo yegazi ngemuva kwamasonto ayisikhombisa.

Abanye abasebenzisi bavuma ukuthi isengezo sadlala indima enkulu ekwehliseni umfutho wegazi labo.

  • Yehlisa I-Cholesterol Yegazi

Uma ukhuluphele kakhulu, amathuba ukuthi amazinga akho cholesterol aphakeme. I-SR9009 izonciphisa ifike ku-47% ye-LDL, ngaleyo ndlela yenze ukusebenzisa kwakho kube nokukhiqizayo. Kufanele wazi ukuthi isengezo asithinti amazinga e-HDL.

  • Kwehlisa Ukuvuvukala

I-Rev-Erbs idlala indima ebalulekile ekulawuleni ukuvuvukala nokulimala ngaphakathi kwe-CNS. I-SR9009 ivuselela ama-receptors enuzi ka-Rev-Erbcy, anemiphumela yokulwa nokuvuvukala.

Umuthi ucindezela ukukhiqizwa kwama-molecule wokuvuvukala njenge CCL2, MMP-9, kanye ne-TNF-α. Njengoba ukulimala kwezicubu nokuvuvukala okungapheli kuyizici ze-oncogenic, ososayensi bacwaninga ngamathemba wokuphikisana nomdlavuza we-SR9009 ku-sencocence.

  • Yehlisa ukukhathazeka

I-SR9009 inciphisa ukukhathazeka kumamodeli wamagundane.

  • Awukho umjovo

Uma une-trypanophobia, kunezindaba ezimnandi kuwe. Yebo, i-SR9009 iyatholakala ekuphatheni ngomlomo. Akusekho imijovo ebuhlungu, njengoba kunjalo ngezidakamizwa eziningi ezishisa amafutha.

 

Umhlahlandlela Ophelele Wokuthenga 2019 We-SR9009 Wokwakha Imisipha Engaphezulu

 

I-5.Half Impilo ye-SR9009

Isikhathi sempilo se-SR9009 sifushane njengamahora amane. Ngalesi sizathu, kufanele uhlukanise isilinganiso sakho ngezikhathi zamahora amane ukuze uzinze ukutholakala komuthi egazini.

 

6.SR9009 Umthamo kanye nokuhamba ngebhayisikile

Ama-hingeges we-SR9009 ezintweni ezimbalwa. Lokho, lokho ofisa ukukufeza nokuthi ngabe ufaka ezinye izithako kumjikelezo wakho. Ngaphandle kwalokho, inani lemithi kadokotela nalo lincike ekutheni umzimba wakho usabela kanjani.

Umthamo ojwayelekile yi-30mg ngosuku, ongawuhlukanisa ube yimithamo emithathu ehlukene. Ngokweqiniso, lo muthi usho ukuthi kufanele uphathe iphilisi ngaphambi kokudla noma yikuphi ukudla kwakho okuyisikwele. Esikhundleni salokho, ungasebenzisa isengezo ngemuva kwamahora amane.

Isikhathi esiningi, ukwahlukanisa i-SR9009 powder (1379686-30-2) i-preout yokuzivocavoca ngaphambi kokusebenza kungaba nzima kakhulu, ikakhulukazi kubasebenzisi abangakhathali. Ubani ongathatha ngisho nomuthi ngezikhathi ezithile ngaphandle kwamahora amane ngaphandle kokuphikisana? Ngakho-ke, uma ungakhululeki ngalolu hlelo lwe-dosing, unganquma ukulisebenzisa ihora ngaphambi kokwenza umsebenzi wokuzivocavoca.

Umjikelezo we-SR9009 uqhubeka phakathi kwamasonto ayisishiyagalombili kuya kwayishumi nambili. Njengoba kunamathuba okuthi ubekezeleleke kulo muthi, kufanelekile ukuthatha i-8-sonto off.

Lesi sidakamizwa asithinti isibindi noma izinso. Noma kunjalo, ungavikela lezi zitho ngokufaka ezinye izithasiselo ezibalulekile zokuvikela njenge-N2Guard kumjikelezo wakho we-SR9009.

 

I-7.Udinga i-PCT ye-SR9009?

Ngokungafani nezinye izithasiselo, i-stenabolic ayidingi I-PCT (I-Post Cycle Therapy) ngoba umuthi awuphazamisi amazinga we testosterone.

 

I-8.Ingabakhona Imiphumela Emibi Yesibi Nezingozi Zokusebenzisa kwe-SR9009

  • isiyezi
  • induna
  • bekhanda
  • I-reflux ye-Acid
  • Insomnia

Izimpawu ezingenhla zizothinta ikakhulukazi abaqalayo. Lapho umzimba wakho usuvumelanisa nesengezo, izimpawu ziyophela. Noma kunjalo, uma imiphumela emibi ye-SR9009 iba yimbi kakhulu, kufanele uyilahle bese ukhuluma nodokotela wakho.

I-SR9009 kungenzeka ibe yimbi kakhulu imeko yamadoda anamandla aphansi we-libido noma erectile dysfunctions. Ngesinye isikhathi, isengezo siholela emazingeni aphansi e-testosterone.

I-Stenabolic akuyona i i-steroid. Ngakho-ke, ukuyithatha ngeke kuphazamise uhlelo lwe-hormonal. Izinga lakho le-testosterone ngeke lehle, futhi nomuthi awunakungenisa i-estrogen. Kwabesifazane, isengezo ngeke siholele kumjikelezo wokuya esikhathini ngokungajwayelekile.

 

Umhlahlandlela Ophelele Wokuthenga 2019 wokwakha i-SR9009 SARM

 

I-9.Stacking SR9009 nezinye i-SARM

  • I-SR9009 vs. Ostarine

Kuboshwe i-SR9009 nge I-Ostarine (MK-2866) izothola imiphumela ekhethekile, ikakhulukazi esigabeni sokubuyiselwa kwemali.

I-Ostarine ngokwayo, iyi-SARM enhle kakhulu yemijikelezo eminingi yokusika neyokusika. Kodwa-ke, uma ufuna ukukhuthazela okuphezulu, kufanele uyihambise nge-SR9009. Ngenkathi usesitayeleni, qiniseka ukusebenzisa i-25mg ye-ostarine nsuku zonke. Okwe-stenabolic, i-10mg izosebenza, kepha kufanele uyithathe lapho usuzoshaya isikhungo sokuqina.

  • SR9009 vs. GW 501516

I-SR9009 ne-GW501516 (I-Cardarine) babe nokufana. Olunye ucwaningo luze luveze ukuthi lezi zingxube ezimbili zibopha ama-receptors afanayo.

Njengoba usuvele wazi, i-stenabolic ine-half-life esheshayo, engeke ikugcine usuku lonke. Ngokuphambene nalokho, ukutholakala kwe-cardarine kufinyelela emahoreni angama-24. Ukuhlanganiswa kwalaba ababili kuzoholela kumthelela we-24/7.

Uma usebenzisa i-SR9009 eceleni kwe-GW501516, kufanele ucabangele okwangaphambili njengesengezo sangaphambi kokusebenza. Ukusho ukuthi, kufanele uphathe i-stenabolic kuphela ngezinsuku osebenza ngazo.

Lapho usesitaki se-SR9009, isilinganiso siyi-10mg kuphela, okufanele uyithathe ngaphambi nje kokuzivocavoca. Okwe-GW501516, umuthi ofanelekayo ongu-20mg / ngosuku, okufanele uwuphathe ngesidlo sasekuseni sakho.

 

Isipiliyoni se-10.Builder

I-SR9009 yokuthengisa ngokuyinhloko ihlose abakhi bomzimba abalandela ukukhuthazela, ukwanda kokusebenza ngokomzimba, ukululama okusheshayo ekusebenzeni ngaphandle nokwakheka kwemisipha emile.

Ukusuka ekubuyekezweni okuhlukahlukene kwe-inthanethi, abasebenzisi babika ukuthi isengezo sithuthukise ukukhuthazela njengoba bangenza izivivinyo ezinamandla ngaphandle kokuzizwa bekhathele. Kwabanye, ukukhuphuka kwamandla nokuqina kwamandla bekufinyelela ezingeni eliphakeme ngokushesha ngemuva kokuphatha i-SR9009 powder (1379686-30-2).

Ngasohlangothini olubi, abanye abasebenzisi behluleka ukudonsa i-dosing ejwayelekile njalo emahoreni amane. Kodwa-ke, labo abasebenzisa i-SR9009 stacks abakutholanga lokhu kuyinkinga ngoba bekumele bathathe okungezelelweyo ngenkathi belibangise ejimini.

Abathengi abambalwa bavumile ukuthi i-stenabolic ayibenzanga bazizwe kakhulu. Ngaphandle kokuqwasha, akekho obonakala ebhalisa imiphumela emibi ye-SR9009.

 

I-11.Is SR9009 Bioavava?

Kube nokuqagela ukuthi i-SR9009 ine-zero bioavailability, ikakhulukazi ekuphathweni ngomlomo. Kodwa-ke, ngingakuphika ngokuzethemba lokhu ngoba uma isengezo besingatholakali, bekungeke kube nemiphumela emihle ye-SR9009 emzimbeni womuntu.

 

I-12.Ingathengwa kuphi i-SR9009

Abathengisi abaningi babeka i-SR9009 ukuthi ithengiswe. Yize izitolo eziku-inthanethi ziyindawo ekahle yokuthenga izengezo, kufanele uqaphele kakhulu ukuthi ungazweli ekuthengeni imikhiqizo yomgunyathi.

Uma ufuna i-stenabolic ebanga lomuntu, yithole kumphakeli odumile. Ungenza i-oda nge I-AASraw.

 

I-13.SR9009 Yokwakha umzimba

I-SR9009 powder (I-1379686-30-2) itheleke embonini yokwakha umzimba lapho ucwaningo luqinisekisa ukuthi isengezo senze amagundane abe nemisipha yokuncipha. Ngaphandle kwalokho, babekhuthele, bekhombisa ukusebenza kahle komzimba, futhi babenamandla kunakuqala.

Abakhi bomzimba ngemuva kokuqunjelwa noma ukusikwa bazozuza ngokuphelele kwi-SR9009. Ezimweni lapho kufanele uqeqeshe kanzima khona, lesi sidakamizwa sikhuphula izinga lokushaya kwenhliziyo yakho, ngaleyo ndlela sinciphise ikhanda elikhanyayo nokukhathala. Ngaphezu kwalokho, isengezo sokwakha umzimba se-SR9009 sinciphisa ukuvuvukala nokonakala kwezicubu ukuze inqubo yokutakula isheshe ngangokunokwenzeka.

 

I-14.Conclusion

Isengezo sokwakha umzimba se-SR9009 sisebenzela ukuthuthukiswa kokusebenza. Okungenani, kukhona ukulingwa okwanele kokuqala kokusekela leli qiniso nokubuyekezwa komsebenzisi okuningana okuhle komkhiqizo.

Kodwa-ke, ukusebenza kahle kwalesi sidakamizwa kube yithambo lombango phakathi kososayensi nabacwaningi nososayensi bebonke. Isibonelo, kube nama-anecdotes okuthi i-SR9009 oral bioavailability ingu-zero. Hhayi, angifisi ukwenza njengommeli kasathane, kepha ama-95% wabasebenzisi be-stenabolic baqinisekisa ukusebenza kwayo. Ngaphandle kwalokho, kufanele ngabe ubuza ukuthi kungani izinhlangano ezilwa nokusetshenziswa kwezidakamizwa zingaba nesibindi sokuvimba ukusetshenziswa kwazo kwezemidlalo lapho into ingasebenzi kahle.

Qaphela ukuthi imiphumela ye-SR9009 ibonakala lapho usebenza njalo ngenkathi udla ukudla okunempilo. Gwema ukudla okunamafutha, amakhalori, nokunqenqemeni kokubhema nokubhema.

 

Okubhekwayo

  1. Cho, H., Zhao, X. et al. (2012). Ukulawulwa kwe-Circadian Behavior and Metabolism ka-REV-ERBα ne-REV-ERBβ. IGene Expression Laboratory, iSalk Institute for Biological Study.
  2. IMorioka, N., Zhang, FF, Tomori, M., Hisaoka-Nakashima, K., Saeki, M., kanye noNakata, Y. (2016). Ukugqugquzelwa kwe-NViths Receptor REV-ERBs ilawula i-Tumor Necrosis Factor-Ebonisa Ukuvezwa Kwemolekyuli Ekulimaza Kumaseli e-C6 Astroglial Cell.
  3. Amakhaya, i-PG, iBrandon-Warner, i-E, et al. (2016). I-Rev-Erb Agonist ne-TGF-β Ngokufanayo Thinta i-Autophagy kodwa Ngokuhlukile Lawula i-Hepatic Stellate Cell Fibrogenic Phenotype. Int J Biochem Cell Biol.
  4. UDodson, B. (2013). Izidakamizwa Ezintsha Zilingisa Imiphumela Ezuzisayo Yokuzivocavoca. Ezempilo nokuPhepha.
  5. Woldt, E., Sebti, Y. Et al. (2013). I-Rev-Erbα Modulates Skeletal Muscle Oxidative Capacity ngokulawula i-Mitochondrial Biogenesis ne-Autophagy. Ijenali Yemithi Yemvelo.
  6. USulli, G., Rommel, A., et al. (2018). I-Pharmacological activation ye-REV-ERBs i-Lethal in Cancer kanye ne-Oncogene-Indedu Senescence. Imvelo (Ijenali Yangaphakathi Yesayensi).
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